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Title: The systemic inflammome of severe obesity before and after bariatric surgery
Author: Arismendi, Ebymar
Riva, Eva
Agustí García-Navarro, Àlvar
Ríos, José
Barreiro, Esther
Vidal i Cortada, Josep
Rodríguez-Roisin, Robert
Keywords: Obesitat mòrbida
Marcadors bioquímics
Cirurgia de l'obesitat
Morbid obesity
Biochemical markers
Obesity surgery
Issue Date: 19-Sep-2014
Publisher: Public Library of Science (PLoS)
Abstract: INTRODUCTION: Obesity is associated with low-grade systemic inflammation. The 'inflammome' is a network layout of the inflammatory pattern. The systemic inflammome of obesity has not been described as yet. We hypothesized that it can be significantly worsened by smoking and other comorbidities frequently associated with obesity, and ameliorated by bariatric surgery (BS). Besides, whether or not these changes are mirrored in the lungs is unknown, but obesity is often associated with pulmonary inflammation and bronchial hyperresponsiveness. OBJECTIVES: We sought to: (1) describe the systemic inflammome of morbid obesity; (2) investigate the effects of sex, smoking, sleep apnea syndrome, metabolic syndrome and BS upon this systemic inflammome; and, (3) determine their interplay with pulmonary inflammation. METHODS: We studied 129 morbidly obese patients (96 females; age 46 ± 12 years; body mass index [BMI], 46 ± 6 kg/m2) before and one year after BS, and 20 healthy, never-smokers, (43 ± 7 years), with normal BMI and spirometry. RESULTS: Before BS, compared with controls, all obese subjects displayed a strong and coordinated (inflammome) systemic inflammatory response (adiponectin, C-reactive protein, interleukin (IL)-8, IL-10, leptin, soluble tumor necrosis factor-receptor 1(sTNF-R1), and 8-isoprostane). This inflammome was not modified by sex, smoking, or coexistence of obstructive sleep apnea and/or metabolic syndrome. By contrast, it was significantly ameliorated, albeit not completely abolished, after BS. Finally, obese subjects had evidence of pulmonary inflammation (exhaled condensate) that also decreased after BS. CONCLUSIONS: The systemic inflammome of morbid obesity is independent of sex, smoking status and/or comorbidities, it is significantly reduced by BS and mirrored in the lungs.
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It is part of: PLoS One, 2014, vol. 9, num. 9, p. e107859
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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