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Title: Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns
Author: Sanchez-Mut, Jose Vicente
Heyn, Holger
Vidal, Enrique
Moran, Sebastian
Sayols, Sergi
Delgado-Morales, Raúl
Schultz, M. D.
Ansoleaga, Belén
Garcia Esparcia, Paula
Pons-Espinal, Meritxell
Lagran, M. M. de
Dopazo, Joaquín
Rabano, A.
Avila, Jesús
Dierssen, Mara
Lott, I.
Ferrer, Isidro (Ferrer Abizanda)
Ecker, J. R.
Esteller, Manel
Keywords: Epigènesi
Malalties neurodegeneratives
Sistema nerviós
Neurodegenerative diseases
Nervous system
Issue Date: 19-Jan-2016
Publisher: Nature Publishing Group
Abstract: Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared epigenetic aberrations, such as those affecting DNA methylation, might also exist. The studied samples were gray matter samples from the prefrontal cortex of control and neurodegenerative disease-associated cases. We performed the DNA methylation analyses of Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease and Alzheimer-like neurodegenerative profile associated with Down's syndrome samples. The DNA methylation landscapes obtained show that neurodegenerative diseases share similar aberrant CpG methylation shifts targeting a defined gene set. Our findings suggest that neurodegenerative disorders might have similar pathogenetic mechanisms that subsequently evolve into different clinical entities. The identified aberrant DNA methylation changes can be used as biomarkers of the disorders and as potential new targets for the development of new therapies.
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It is part of: Translational Psychiatry, 2016, vol. 6, p. e718
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ISSN: 2158-3188
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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