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Title: Modulation of higher-order olfaction components on executive functions in humans
Author: Fagundo, Ana Beatriz
Jiménez-Murcia, Susana
Giner Bartolomé, Cristina
Islam, Mohammed Anisul
Torre Fornell, Rafael de la
Pastor Bosch, Antonio
Casanueva, Felipe F.
Crujeiras, Ana B.
Granero, Roser
Baños Rivera, Rosa María
Botella Arbona, Cristina
Fernández-Real Lemos, José Manuel
Frühbeck, Gema
Gómez Ambrosi, Javier
Menchón Magriñá, José Manuel
Tinahones, Francisco J.
Fernández Aranda, Fernando
Keywords: Olfacte
Lòbul frontal
Frontal lobe
Issue Date: 17-Jun-2015
Publisher: Public Library of Science (PLoS)
Abstract: The prefrontal (PFC) and orbitofrontal cortex (OFC) appear to be associated with both exec- utive functions and olfaction. However, there is little data relating olfactory processing and executive functions in humans. The present study aimed at exploring the role of olfaction on executive functioning, making a distinction between primary and more cognitive aspects of olfaction. Three executive tasks of similar difficulty were used. One was used to assess hot executive functions (Iowa Gambling Task-IGT), and two as a measure of cold executive functioning (Stroop Colour and Word Test-SCWT and Wisconsin Card Sorting Test- WCST). Sixty two healthy participants were included: 31 with normosmia and 31 with hyposmia. Olfactory abilities were assessed using the '' Sniffin ' Sticks '' test and the olfactory threshold, odour discrimination and odour identification measures were obtained. All partici- pants were female, aged between 18 and 60. Results showed that participants with hypos- mia displayed worse performance in decision making (IGT; Cohen ' s- d = 0.91) and cognitive flexibility (WCST; Cohen ' s- d between 0.54 and 0.68) compared to those with normosmia. Multiple regression adjusted by the covariates participants ' age and education level showed a positive association between odour identification and the cognitive inhibition response (SCWT-interference; Beta = 0.29; p = .034). The odour discrimination capacity was not a predictor of the cognitive executive performance. Our results suggest that both hot and cold executive functions seem to be associated with higher-order olfactory functioning in humans. These results robustly support the hypothesis that olfaction and executive mea- sures have a common neural substrate in PFC and OFC, and suggest that olfaction might be a reliable cognitive marker in psychiatric and neurologic disorders.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2015, vol. 10, num. 6, p. e0130319
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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