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http://hdl.handle.net/2445/111525
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DC Field | Value | Language |
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dc.contributor.author | García-Albéniz, Xavier | - |
dc.contributor.author | Gallego, Rosa | - |
dc.contributor.author | Hofhteinz, Ralf Dieter | - |
dc.contributor.author | Fernández Esparrach, Glòria | - |
dc.contributor.author | Ayuso Colella, Juan Ramón | - |
dc.contributor.author | Bombí, Josep Antoni | - |
dc.contributor.author | Conill, Carles | - |
dc.contributor.author | Cuatrecasas Freixas, Miriam | - |
dc.contributor.author | Delgado Rivilla, Salvadora | - |
dc.contributor.author | Ginès i Gibert, M. Àngels | - |
dc.contributor.author | Miquel Morera, Rosa | - |
dc.contributor.author | Pagès Llinàs, M. (Mario) | - |
dc.contributor.author | Pineda, Estela | - |
dc.contributor.author | Pereira, María Verónica | - |
dc.contributor.author | Sosa, Aarón | - |
dc.contributor.author | Reig Torras, Oscar | - |
dc.contributor.author | Victoria, Iván | - |
dc.contributor.author | Feliz, Luis | - |
dc.contributor.author | Lacy Fortuny, Antonio Ma. de | - |
dc.contributor.author | Castells Garangou, Antoni | - |
dc.contributor.author | Burkholder, Iris | - |
dc.contributor.author | Hochhaus, Andreas | - |
dc.contributor.author | Maurel Santasusana, Joan | - |
dc.date.accessioned | 2017-05-25T07:54:10Z | - |
dc.date.available | 2017-05-25T07:54:10Z | - |
dc.date.issued | 2014-11-14 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | http://hdl.handle.net/2445/111525 | - |
dc.description.abstract | AIM: To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy. METHODS: Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy. Laparoscopic surgery was planned after 5-8 wk. Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol. Patients with ypT1-2N0 or ypT3-4 or N+ were offered 5-fluorouracil-based adjuvant treatment on an individual basis. An external cohort was used as a reference for the findings. RESULTS: One hundred and seventy six patients were treated with induction chemoradiotherapy and 170 underwent total mesorectal excision. Cancer staging of ypT0N0 was achieved in 26/170 (15.3%) patients. After a median follow-up of 58.3 mo, patients with ypT0N0 had five-year disease-free and overall survival rates of 96% (95%CI: 77-99) and 100%, respectively. We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation. The inherent good prognosis of these patients will have implications for clinical trial design and care of patients. CONCLUSION: Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Baishideng Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3748/wjg.v20.i42.15820 | - |
dc.relation.ispartof | World Journal of Gastroenterology, 2014, vol. 20, num. 42, p. 15820-15829 | - |
dc.relation.uri | https://doi.org/10.3748/wjg.v20.i42.15820 | - |
dc.rights | cc-by-nc (c) García-Albéniz, X. et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es | - |
dc.source | Articles publicats en revistes (Fonaments Clínics) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Radioteràpia | - |
dc.subject.classification | Quimioteràpia del càncer | - |
dc.subject.classification | Cirurgia laparoscòpica | - |
dc.subject.classification | Estudi de casos | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Radiotherapy | - |
dc.subject.other | Cancer chemotherapy | - |
dc.subject.other | Laparoscopic surgery | - |
dc.subject.other | Case studies | - |
dc.title | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 645148 | - |
dc.date.updated | 2017-05-25T07:54:11Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25400468 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Fonaments Clínics) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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File | Description | Size | Format | |
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645148.pdf | 1.21 MB | Adobe PDF | View/Open |
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