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Title: Menstrual and Reproductive Factors and Risk of Gastric and Colorectal Cancer in Spain
Author: Lope, Virginia
Fernández de Larrea, Nerea
Pérez Gómez, Beatriz
Martín Sánchez, Vicente
Moreno Aguado, Víctor
Costas, Laura
Longo, Federico
Jiménez-Moleón, José Juan
Llorca Díaz, Javier
Ascunce, Nieves
Peiró Pérez, Rosana
Altzibar, Jone M.
Tardón, Adonina
Alguacil, Juan
Navarro, Carmen
Sierra, Ángeles
Vega, Ana Belén
Villafañe, Amaya
Castaño-Vinyals, Gemma
Kogevinas, Manolis
Pollán, Marina
Aragonès Sanz, Núria
Keywords: Hormones
Càncer colorectal
Hormone therapy
Colorectal cancer
Issue Date: 24-Oct-2016
Publisher: Public Library of Science (PLoS)
Abstract: BACKGROUND: Sex hormones play a role in gastric cancer and colorectal cancer etiology, however, epidemiological evidence is inconsistent. This study examines the influence of menstrual and reproductive factors over the risk of both tumors. METHODS: In this case-control study 128 women with gastric cancer and 1293 controls, as well as 562 female and colorectal cancer cases and 1605 controls were recruited in 9 and 11 Spanish provinces, respectively. Population controls were frequency matched to cases by age and province. Demographic and reproductive data were directly surveyed by trained staff. The association with gastric, colon and rectal cancer was assessed using logistic and multinomial mixed regression models. RESULTS: Our results show an inverse association of age at first birth with gastric cancer risk (five-year trend: OR = 0.69; p-value = 0.006). Ever users of hormonal contraception presented a decreased risk of gastric (OR = 0.42; 95%CI = 0.26-0.69), colon (OR = 0.64; 95%CI = 0.48-0.86) and rectal cancer (OR = 0.61; 95%CI = 0.43-0.88). Postmenopausal women who used hormone replacement therapy showed a decreased risk of colon and rectal tumors. A significant interaction of educational level with parity and months of first child lactation was also observed. CONCLUSION: These findings suggest a protective role of exogenous hormones in gastric and colorectal cancer risk. The role of endogenous hormones remains unclear
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2016, vol. 11, num. 10, p. e0164620-16
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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