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Title: Impact of anxiety symptoms on outcomes of depression: an observational study in Asian patients
Author: Novick, Diego
Montgomery, William
Aguado, Jaume
Peng, Xiaomei
Haro Abad, Josep Maria
Keywords: Ansietat
Depressió psíquica
Mental depression
Issue Date: 11-Apr-2016
Publisher: Dove Medical Press
Abstract: OBJECTIVE: To investigate the impact of anxiety symptoms on depression outcomes in Asian patients with major depressive disorder (MDD) (n=714). METHODS: The 17-item Hamilton Depression Scale (HAMD-17), overall severity, somatic symptoms, and quality of life (QOL) (EuroQOL Questionnaire-5 Dimensions [EQ-5D]) were assessed at baseline and 3 months. Anxiety was measured using items 10 and 11 from the HAMD-17. Linear, tobit, and logistic multiple regression models analyzed the impact of anxiety symptoms on outcomes. Baseline anxiety was related to age and the presence of pain symptoms at baseline. RESULTS: Regression models showed that a higher level of anxiety was associated with a lower frequency of remission and lower QOL at 3 months. Patients with lower baseline anxiety symptoms had higher remission rates (odds ratio for each point of anxiety symptoms, 0.829 [95% confidence interval [CI]: 0.723-0.951]). Patients with higher levels of baseline anxiety had a lower QOL at 3 months (a decrease in EQ-5D tariff score for each point of anxiety symptoms, 0.023 [95% CI: 0.045-0.001]). CONCLUSION: In conclusion, the presence of anxiety symptoms negatively impacts the outcomes of depression.
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It is part of: Neuropsychiatric Disease And Treatment, 2016, vol. 12, p. 795-800
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ISSN: 1176-6328
Appears in Collections:Articles publicats en revistes (Medicina)

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