Please use this identifier to cite or link to this item:
Title: Genetic variants of innate immune receptors and infections after liver transplantation.
Author: Sanclemente, Gemma
Moreno Camacho, Ma. Asunción
Navasa, Miquel
Lozano Soto, Francisco
Cervera, Carlos
Keywords: Trasplantament hepàtic
Hepatic transplantation
Issue Date: 28-Aug-2014
Publisher: Baishideng Publishing Group
Abstract: Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is necessary after transplantation. In this setting, the presence of genetic variants of innate immunity receptors may increase the risk of post-transplant infection, in comparison with patients carrying wild-type alleles. Numerous studies have investigated the role of genetic variants of innate immune receptors and the risk of complication after liver transplantation, but their results are discordant. Toll-like receptors and mannose-binding lectin are arguably the most important studied molecules; however, many other receptors could increase the risk of infection after transplantation. In this article, we review the published studies analyzing the impact of genetic variants in the innate immune system on the development of infectious complications after liver transplantation.
Note: Reproducció del document publicat a:
It is part of: World Journal of Gastroenterology, 2014, vol. 20, num. 32, p. 11116-11130
Related resource:
ISSN: 1007-9327
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Files in This Item:
File Description SizeFormat 
646386.pdf886.26 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons