Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/111962
Title: Genetic variants of innate immune receptors and infections after liver transplantation.
Author: Sanclemente, Gemma
Moreno Camacho, Ma. Asunción
Navasa, Miquel
Lozano Soto, Francisco
Cervera, Carlos
Keywords: Trasplantament hepàtic
Morbiditat
Immunitat
Infeccions
Hepatic transplantation
Morbidity
Immunity
Infections
Issue Date: 28-Aug-2014
Publisher: Baishideng Publishing Group
Abstract: Infection is the leading cause of complication after liver transplantation, causing morbidity and mortality in the first months after surgery. Allograft rejection is mediated through adaptive immunological responses, and thus immunosuppressive therapy is necessary after transplantation. In this setting, the presence of genetic variants of innate immunity receptors may increase the risk of post-transplant infection, in comparison with patients carrying wild-type alleles. Numerous studies have investigated the role of genetic variants of innate immune receptors and the risk of complication after liver transplantation, but their results are discordant. Toll-like receptors and mannose-binding lectin are arguably the most important studied molecules; however, many other receptors could increase the risk of infection after transplantation. In this article, we review the published studies analyzing the impact of genetic variants in the innate immune system on the development of infectious complications after liver transplantation.
Note: Reproducció del document publicat a: https://doi.org/10.3748/wjg.v20.i32.11116
It is part of: World Journal of Gastroenterology, 2014, vol. 20, num. 32, p. 11116-11130
Related resource: https://doi.org/10.3748/wjg.v20.i32.11116
URI: http://hdl.handle.net/2445/111962
ISSN: 1007-9327
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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