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Title: Altered Hypercoagulability Factors in Patients with Chronic Chagas Disease: Potential Biomarkers of Therapeutic. Response
Author: Pinazo, María Jesús
Posada, Elizabeth
Izquierdo, Luis
Tassies, Dolors
Ferreira Marques, Alexandre
Lazzari, Elisa de
Aldasoro, Edelweiss
Muñoz, José
Abras Feliu, Alba
Tebar, Silvia
Gállego Culleré, M. (Montserrat)
Almeida, Igor C.
Reverter, Joan Carles
Gascón i Brustenga, Joaquim
Keywords: Hemostàsia
Malalties parasitàries
Malaltia de Chagas
Parasitic diseases
Chagas' disease
Issue Date: 2016
Publisher: Public Library of Science (PLoS)
Abstract: Thromboembolic events were described in patients with Chagas disease without cardiomyopathy. We aim to confirm if there is a hypercoagulable state in these patients and to determine if there is an early normalization of hemostasis factors after antiparasitic treatment. Ninety-nine individuals from Chagas disease-endemic areas were classified in two groups: G1, with T.cruzi infection (n = 56); G2, healthy individuals (n = 43). Twenty-four hemostasis factors were measured at baseline. G1 patients treated with benznidazole were followed for 36 months, recording clinical parameters and performance of conventional serology, chemiluminescent enzyme-linked immunosorbent assay (trypomastigote-derived glycosylphosphatidylinositol-anchored mucins), quantitative polymerase chain reaction, and hemostasis tests every 6-month visits. Prothrombin fragment 1+2 (F1+2) and endogenous thrombin potential (ETP) were abnormally expressed in 77% and 50% of infected patients at baseline but returned to and remained at normal levels shortly after treatment in 76% and 96% of cases, respectively. Plasmin-antiplasmin complexes (PAP) were altered before treatment in 32% of G1 patients but normalized in 94% of cases several months after treatment. None of the patients with normal F1+2 values during follow-up had a positive qRT-PCR result, but 3/24 patients (13%) with normal ETP values did. In a percentage of chronic T. cruzi infected patients treated with benznidazole, altered coagulation markers returned into normal levels. F1+2, ETP and PAP could be useful markers for assessing sustained response to benznidazole.
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It is part of: PLoS Neglected Tropical Diseases, 2016, vol. 10, num. 1, p. e0004269
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ISSN: 1935-2735
Appears in Collections:Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)
Articles publicats en revistes (ISGlobal)

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