Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/112008
Title: Urine Monocyte Chemoattractant Protein-1 Is an Independent Predictive Factor of Hospital Readmission and Survival in Cirrhosis.
Author: Graupera, Isabel
Solà, Elsa
Fabrellas i Padrès, Núria
Moreira, Rebeca
Solé, Cristina
Huelin, Patricia
de la Prada, Gloria
Pose, Elisa
Ariza Cardenal, Javier
Risso, Alessandro
Albertos, Sonia
Morales Ruiz, Manuel
Jiménez Povedano, Wladimiro
Ginès i Gibert, Pere
Keywords: Cirrosi hepàtica
Orina
Creatina
Inflamació
Ascites
Hepatic cirrhosis
Urine
Creatine
Inflammation
Ascites
Issue Date: 30-Jun-2016
Publisher: Public Library of Science (PLoS)
Abstract: MCP-1 (monocyte chemoattractant protein-1) is a proinflammatory cytokine involved in chemotaxis of monocytes. In several diseases, such as acute coronary syndromes and heart failure, elevated MCP-1 levels have been associated with poor outcomes. Little is known about MCP-1 in cirrhosis. AIM: To investigate the relationship between MCP-1 and outcome in decompensated cirrhosis. METHODS: Prospective study of 218 patients discharged from hospital after an admission for complications of cirrhosis. Urine and plasma levels of MCP-1 and other urine proinflammatroy biomarkers: osteopontin(OPN), trefoil-factor3 and liver-fatty-acid-binding protein were measured at admission. Urine non-inflammatory mediators cystatin-C, β2microglobulin and albumin were measured as control biomarkers. The relationship between these biomarkers and the 3-month hospital readmission, complications of cirrhosis, and mortality were assessed. RESULTS: 69 patients(32%) had at least one readmission during the 3-month period of follow-up and 30 patients died(14%). Urine MCP-1 and OPN levels, were associated with 3-month probability of readmission (0.85 (0.27-2.1) and 2003 (705-4586) ug/g creat vs 0.47 (0.2-1.1) and 1188 (512-2958) ug/g creat, in patients with and without readmission, respectively; p<0.05; median (IQR)). Furthermore, urine levels of MCP-1 were significantly associated with mortality (1.01 (1-3.6) vs 0.5 (0.2-1.1) μg/g creat, in dead and alive patients at 3 months; p<0.05). Patients with higher levels of urine MCP-1 (above percentile 75th) had higher probability of development of hepatic encephalopathy, bacterial infections or AKI. Urine MCP-1 was an independent predictive factor of hospital readmission and combined end-point of readmission or dead at 3 months. Plasma levels of MCP-1 did not correlated with outcomes. CONCLUSION: Urine, but not plasma, MCP-1 levels are associated with hospital readmission, development of complications of cirrhosis, and mortality. These results suggest that in cirrhosis there is an inflammatory response that is associated with poor outcomes.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0157371
It is part of: PLoS One, 2016, vol. 11, num. 6
Related resource: https://doi.org/10.1371/journal.pone.0157371
URI: http://hdl.handle.net/2445/112008
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Files in This Item:
File Description SizeFormat 
666256.pdf763.75 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons