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Title: | Predicting Response Trajectories during Cognitive-Behavioural Therapy for Panic Disorder: No Association with the BDNF Gene or Childhood Maltreatment. |
Author: | Santacana, Marti Arias Sampériz, Bárbara Mitjans Niubó, Marina Bonillo, Albert Montoro, Maria Rosado, Silvia Guillamat, Roser Vallès, Vicenç Pérez, Víctor Forero, Carlos G. Fullana, Miquel A. |
Keywords: | Ansietat Trastorns de pànic Maltractament infantil Genètica humana Polimorfisme genètic Anxiety Panic disorders Child abuse Human genetics Genetic polymorphisms |
Issue Date: | 29-Jun-2016 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | BACKGROUND: Anxiety disorders are highly prevalent and result in low quality of life and a high social and economic cost. The efficacy of cognitive-behavioural therapy (CBT) for anxiety disorders is well established, but a substantial proportion of patients do not respond to this treatment. Understanding which genetic and environmental factors are responsible for this differential response to treatment is a key step towards 'personalized medicine'. Based on previous research, our objective was to test whether the BDNF Val66Met polymorphism and/or childhood maltreatment are associated with response trajectories during exposure-based CBT for panic disorder (PD). METHOD: We used Growth Mixture Modeling to identify latent classes of change (response trajectories) in patients with PD (N = 97) who underwent group manualized exposure-based CBT. We conducted logistic regression to investigate the effect on these trajectories of the BDNF Val66Met polymorphism and two different types of childhood maltreatment, abuse and neglect. RESULTS: We identified two response trajectories ('high response' and 'low response'), and found that they were not significantly associated with either the genetic (BDNF Val66Met polymorphism) or childhood trauma-related variables of interest, nor with an interaction between these variables. CONCLUSIONS: We found no evidence to support an effect of the BDNF gene or childhood trauma-related variables on CBT outcome in PD. Future studies in this field may benefit from looking at other genotypes or using different (e.g. whole-genome) approaches. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0158224 |
It is part of: | PLoS One, 2016, vol. 11, num. 6, p. e0158224 |
URI: | http://hdl.handle.net/2445/112016 |
Related resource: | https://doi.org/10.1371/journal.pone.0158224 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) |
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