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Title: Predicting Response Trajectories during Cognitive-Behavioural Therapy for Panic Disorder: No Association with the BDNF Gene or Childhood Maltreatment.
Author: Santacana, Marti
Arias Sampériz, Bárbara
Mitjans Niubó, Marina
Bonillo, Albert
Montoro, Maria
Rosado, Silvia
Guillamat, Roser
Vallès, Vicenç
Pérez, Victor
Forero, Carlos G
Fullana, Miquel A
Keywords: Ansietat
Trastorns de pànic
Maltractament infantil
Genètica humana
Polimorfisme genètic
Panic disorders
Child abuse
Human genetics
Genetic polymorphisms
Issue Date: 29-Jun-2016
Publisher: Public Library of Science (PLoS)
Abstract: BACKGROUND: Anxiety disorders are highly prevalent and result in low quality of life and a high social and economic cost. The efficacy of cognitive-behavioural therapy (CBT) for anxiety disorders is well established, but a substantial proportion of patients do not respond to this treatment. Understanding which genetic and environmental factors are responsible for this differential response to treatment is a key step towards 'personalized medicine'. Based on previous research, our objective was to test whether the BDNF Val66Met polymorphism and/or childhood maltreatment are associated with response trajectories during exposure-based CBT for panic disorder (PD). METHOD: We used Growth Mixture Modeling to identify latent classes of change (response trajectories) in patients with PD (N = 97) who underwent group manualized exposure-based CBT. We conducted logistic regression to investigate the effect on these trajectories of the BDNF Val66Met polymorphism and two different types of childhood maltreatment, abuse and neglect. RESULTS: We identified two response trajectories ('high response' and 'low response'), and found that they were not significantly associated with either the genetic (BDNF Val66Met polymorphism) or childhood trauma-related variables of interest, nor with an interaction between these variables. CONCLUSIONS: We found no evidence to support an effect of the BDNF gene or childhood trauma-related variables on CBT outcome in PD. Future studies in this field may benefit from looking at other genotypes or using different (e.g. whole-genome) approaches.
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It is part of: PLoS One, 2016, vol. 11, num. 6, p. e0158224
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

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