Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/112018
Title: Effect of osteoprotegerin and Dickkopf-related protein 1 on radiological progression in tightly controlled rheumatoid arthritis.
Author: Gómez Vaquero, Carmen
Martín, Irene
Loza, Estibaliz
Carmona Ortells, Loreto
Ivorra, José
Narváez, José A
Hernández Gañán, Javier
Alía Ramos, Pedro
Narváez, Javier
Keywords: Artritis reumatoide
Articulacions
Osteòlisi
Rheumatoid arthritis
Joints
Bone resorption
Issue Date: 2-Dec-2016
Publisher: Public Library of Science (PLoS)
Abstract: OBJECTIVE: To analyze the association between circulating osteoprotegerin (OPG) and Dickkopf-related protein 1 (DKK-1) and radiological progression in patients with tightly controlled rheumatoid arthritis (RA). METHODS: Serum levels of OPG and DKK-1 were measured in 97 RA patients who were treated according to a treat-to-target strategy (T2T) aimed at remission (DAS28<2.6). Radiologic joint damage progression was assessed by changes in the total Sharp-van der Heijde score (SHS) on serial radiographs of the hands and feet. The independent association between these biomarker levels and the structural damage endpoint was examined using regression analysis. RESULTS: The mean age of the 97 RA patients (68 women) at the time of the study was 54 ± 14 years, and the median disease duration was 1.6 ± 1.5 years. Most patients were seropositive for either RF or ACPA, and the large majority (76%) were in remission or had low disease activity. After a median follow-up time of 3.3 ± 1.5 years (range, 1-7.5 yrs.), the mean total SHS annual progression was 0.88 ± 2.20 units. Fifty-two percent of the patients had no progression (defined as a total SHS of zero). The mean serum OPG level did not change significantly over the study period (from 3.9 ± 1.8 to 4.07 ± 2.23 pmol/L), whereas the mean serum DKK-1 level decreased, although not significantly (from 29.9 ± 10.9 to 23.6 ± 18.8 pmol/L). In the multivariate analysis, the predictive factors increasing the likelihood of total SHS progression were age (OR per year = 1.10; p = 0.003) and a high mean C-reactive protein level over the study period (OR = 1.29; p = 0.005). Circulating OPG showed a protective effect reducing the likelihood of joint space narrowing by 60% (95% CI: 0.38-0.94) and the total SHS progression by 48% (95% CI: 0.28-0.83). The DKK-1 levels were not associated with radiological progression. CONCLUSION: In patients with tightly controlled RA, serum OPG was inversely associated with progression of joint destruction. This biomarker may be useful in combination with other risk factors to improve prediction in patients in clinical remission or low disease activity state.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0166691
It is part of: PLoS One, 2016, vol. 11, num. 12, p. e0166691
Related resource: https://doi.org/10.1371/journal.pone.0166691
URI: http://hdl.handle.net/2445/112018
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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