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http://hdl.handle.net/2445/112164
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DC Field | Value | Language |
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dc.contributor.author | Martínez de Paz, Alexia | - |
dc.contributor.author | Vicente Sanchez Mut, Jose | - |
dc.contributor.author | Samitier Martí, Mireia | - |
dc.contributor.author | Petazzi, Paolo | - |
dc.contributor.author | Sáez, Mauricio | - |
dc.contributor.author | Szczesna, Karolina | - |
dc.contributor.author | Huertas, Dori | - |
dc.contributor.author | Esteller, Manel | - |
dc.contributor.author | Ausió, Juan | - |
dc.date.accessioned | 2017-06-09T10:26:32Z | - |
dc.date.available | 2017-06-09T10:26:32Z | - |
dc.date.issued | 2015-04-13 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/112164 | - |
dc.description.abstract | Abstract Methyl CpG binding protein 2 (MeCP2) is a chromosomal protein of the brain, very abundant especially in neurons, where it plays an important role in the regulation of gene expression. Hence it has the potential to be affected by the mammalian circadian cycle. We performed expression analyses of mice brain frontal cortices obtained at different time points and we found that the levels of MeCP2 are altered circadianly, affecting overall organization of brain chromatin and resulting in a circadian-dependent regulation of well-stablished MeCP2 target genes. Furthermore, this data suggests that alterations of MeCP2 can be responsible for the sleeping disorders arising from pathological stages, such as in autism and Rett syndrome. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0123693 | - |
dc.relation.ispartof | PLoS One, 2015 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0123693 | - |
dc.rights | cc-by (c) Martínez de Paz, Alexia et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Ritmes circadiaris | - |
dc.subject.classification | Cromatina | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.other | Circadian rhythms | - |
dc.subject.other | Chromatin | - |
dc.subject.other | Gene expression | - |
dc.title | Circadian cycle-dependent MeCP2 and brain chromatin changes | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 662728 | - |
dc.date.updated | 2017-06-09T10:26:32Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/268626/EU//EPINORC | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/238242/EU//DISCHROM | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25875630 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
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662728.pdf | 1.45 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License