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Title: The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures
Author: Mir Morro, Bartomeu
Solés, X.
González, Carlos
Escaja Sánchez, Nuria
Keywords: Àcids nucleics
Citidina difosfat de colina
Nucleic acids
Cytidine diphosphate choline
Issue Date: 5-Jun-2017
Publisher: Nature Publishing Group
Abstract: Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C+ stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C+ or psC:psC+ hemiprotonated base pairs are formed instead of their neutral analogs. Overall, our results suggest that positively charged base pairs are necessary to stabilize this non-canonical DNA structure.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2017, vol. 7, num. 2772
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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