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http://hdl.handle.net/2445/112375| Title: | The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures |
| Author: | Mir Morro, Bartomeu Solés, X. González, Carlos Escaja Sánchez, Nuria |
| Keywords: | Àcids nucleics Citidina difosfat de colina Oligonucleòtids Nucleic acids Cytidine diphosphate choline Oligonucleotides |
| Issue Date: | 5-Jun-2017 |
| Publisher: | Nature Publishing Group |
| Abstract: | Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C+ stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C+ or psC:psC+ hemiprotonated base pairs are formed instead of their neutral analogs. Overall, our results suggest that positively charged base pairs are necessary to stabilize this non-canonical DNA structure. |
| Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-02723-y |
| It is part of: | Scientific Reports, 2017, vol. 7, num. 2772 |
| URI: | http://hdl.handle.net/2445/112375 |
| Related resource: | https://doi.org/10.1038/s41598-017-02723-y |
| ISSN: | 2045-2322 |
| Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
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|---|---|---|---|---|
| 672099.pdf | 2.56 MB | Adobe PDF | View/Open |
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