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http://hdl.handle.net/2445/112425
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DC Field | Value | Language |
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dc.contributor.author | Molins Monteys, Blanca | - |
dc.contributor.author | Fuentes Prior, Pablo | - |
dc.contributor.author | Adán Civera, Alfredo | - |
dc.contributor.author | Antón, Rosa | - |
dc.contributor.author | Aróstegui Gorospe, Juan Ignacio | - |
dc.contributor.author | Yagüe, Jordi | - |
dc.contributor.author | Dick, Andrew D. | - |
dc.date.accessioned | 2017-06-15T15:06:02Z | - |
dc.date.available | 2017-06-15T15:06:02Z | - |
dc.date.issued | 2016-03-10 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/112425 | - |
dc.description.abstract | Inflammation and immune-mediated processes are pivotal to the pathogenic progression of age-related macular degeneration (AMD). Although plasma levels of C-reactive protein (CRP) have been shown to be associated with an increased risk for AMD, the pathophysiological importance of the prototypical acute-phase reactant in the etiology of the disease is unknown, and data regarding the exact role of CRP in ocular inflammation are limited. In this study, we provide mechanistic insight into how CRP contributes to the development of AMD. In particular, we show that monomeric CRP (mCRP) but not the pentameric form (pCRP) upregulates IL-8 and CCL2 levels in retinal pigment epithelial cells. Further, we show that complement factor H (FH) binds mCRP to dampen its proinflammatory activity. FH from AMD patients carrying the 'risk' His402 polymorphism displays impaired binding to mCRP, and therefore proinflammatory effects of mCRP remain unrestrained. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/srep22889 | - |
dc.relation.ispartof | Scientific Reports, 2016, vol. 6, num. 22889, p. 1-12 | - |
dc.relation.uri | https://doi.org/10.1038/srep22889 | - |
dc.rights | cc-by (c) Molins Monteys, Blanca et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Malalties de la retina | - |
dc.subject.classification | Degeneració (Patologia) | - |
dc.subject.classification | Malalties de les persones grans | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Retinal diseases | - |
dc.subject.other | Degeneration (Pathology) | - |
dc.subject.other | Older people diseases | - |
dc.title | Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 666291 | - |
dc.date.updated | 2017-06-15T15:06:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26961257 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
Files in This Item:
File | Description | Size | Format | |
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666291.pdf | 1.17 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License