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Title: GLP-1 and glucose tolerance after sleeve gastrectomy in morbidly obese subjects with type 2 diabetes.
Author: Jiménez, Amanda
Mari, Andrea
Casamitjana i Abellà, Roser
Lacy Fortuny, Antonio Ma. de
Ferrannini, Ele
Vidal i Cortada, Josep
Keywords: Obesitat mòrbida
Diabetis no-insulinodependent
Cirurgia digestiva
Estudi de casos
Morbid obesity
Non-insulin-dependent diabetes
Gastrointestinal surgery
Case studies
Issue Date: 21-May-2014
Publisher: American Diabetes Association
Abstract: Although GLP-1 has been suggested as a major factor for the marked improvement of glucose tolerance commonly seen after sleeve gastrectomy (SG), several observations challenge this hypothesis. To better understand the role of GLP-1 in the remission of type 2 diabetes mellitus (T2DM) long term after SG in humans, we conducted two separate cross-sectional studies: 1) the GLP-1 response to a standardized mixed liquid meal (SMLM) was compared in subjects with T2DM antedating SG but with different long-term (>2 years) T2DM outcomes (remission, relapse, or lack of remission) (study 1) and 2) the effect of GLP-1 receptor blockade with exendin (9-39) on glucose tolerance was examined in subjects with T2DM antedating surgery, who had undergone SG and presented with long-term T2DM remission (study 2). In study 1, we observed a comparable GLP-1 response to the SMLM regardless of the post-SG outcome of T2DM. In study 2, the blockade of GLP-1 action resulted in impaired insulin secretion but limited deterioration of glucose tolerance. Thus, our data suggest the enhanced GLP-1 secretion observed long term after SG is neither sufficient nor critical to maintain normal glucose tolerance in subjects with T2DM antedating the surgery.
Note: Reproducció del document publicat a:
It is part of: Diabetes, 2014, vol. 63, num. 10, p. 3372-3377
Related resource:
ISSN: 0012-1797
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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