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dc.contributor.authorJiménez, Amanda-
dc.contributor.authorMari, Andrea-
dc.contributor.authorCasamitjana i Abellà, Roser-
dc.contributor.authorLacy Fortuny, Antonio Ma. de-
dc.contributor.authorFerrannini, Ele-
dc.contributor.authorVidal i Cortada, Josep-
dc.description.abstractAlthough GLP-1 has been suggested as a major factor for the marked improvement of glucose tolerance commonly seen after sleeve gastrectomy (SG), several observations challenge this hypothesis. To better understand the role of GLP-1 in the remission of type 2 diabetes mellitus (T2DM) long term after SG in humans, we conducted two separate cross-sectional studies: 1) the GLP-1 response to a standardized mixed liquid meal (SMLM) was compared in subjects with T2DM antedating SG but with different long-term (>2 years) T2DM outcomes (remission, relapse, or lack of remission) (study 1) and 2) the effect of GLP-1 receptor blockade with exendin (9-39) on glucose tolerance was examined in subjects with T2DM antedating surgery, who had undergone SG and presented with long-term T2DM remission (study 2). In study 1, we observed a comparable GLP-1 response to the SMLM regardless of the post-SG outcome of T2DM. In study 2, the blockade of GLP-1 action resulted in impaired insulin secretion but limited deterioration of glucose tolerance. Thus, our data suggest the enhanced GLP-1 secretion observed long term after SG is neither sufficient nor critical to maintain normal glucose tolerance in subjects with T2DM antedating the surgery.-
dc.format.extent6 p.-
dc.publisherAmerican Diabetes Association-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofDiabetes, 2014, vol. 63, num. 10, p. 3372-3377-
dc.rightscc-by-nc-nd (c) American Diabetes Association, 2014-
dc.subject.classificationObesitat mòrbida-
dc.subject.classificationDiabetis no-insulinodependent-
dc.subject.classificationCirurgia digestiva-
dc.subject.classificationEstudi de casos-
dc.subject.otherMorbid obesity-
dc.subject.otherNon-insulin-dependent diabetes-
dc.subject.otherGastrointestinal surgery-
dc.subject.otherCase studies-
dc.titleGLP-1 and glucose tolerance after sleeve gastrectomy in morbidly obese subjects with type 2 diabetes.-
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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