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Title: Evidence of association of the NLRP1 gene with giant cell arteritis
Author: Serrano, Aurora
Carmona, F. David
Castañeda, Santos
Solans, Roser
Hernández Rodríguez, José
Cid Xutglà, M. Cinta
Prieto González, Sergio
Miranda Filloy, José A.
Rodríguez Rodríguez, Luis
Morado, Inmaculada C.
Gómez Vaquero, Carmen
Blanco, Ricardo
Sopeña, Bernardo
Ortego Centeno, Norberto
Unzurrunzaga, Ainhoa
Marí-Alfonso, Begoña
Sánchez-Martin, Julio
García-Villanueva, María Jesús
Hidalgo-Conde, Ana
Pazzola, Giulia
Boiardi, Luigi
Salvarani, Carlo
González Gay, Miguel A.
Martín, Javier
Keywords: Arteritis de cèl·lules gegants
Polimorfisme genètic
Giant cell arteritis
Genetic polymorphisms
Issue Date: Apr-2013
Publisher: BMJ Publishing Group
Abstract: Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity. NLRP1 provides a scaffold for the assembly of the inflammasome that activates caspases 1 and 5, required for processing and activation of the proinflammatory cytokines interleukin 1β (IL-1β), IL-18 and IL-33 and promoting inflammation.
Note: Reproducció del document publicat a:
It is part of: Annals of the Rheumatic Diseases, 2013, vol. 72, num. 4, p. 628-630
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ISSN: 0003-4967
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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