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Title: The treatment of oral leukoplakia with the CO2 laser: A retrospective study of 65 patients
Author: Mogedas-Vegara, Alfonso
Hueto-Madrid, Juan-Antonio
Chimenos Küstner, Eduardo
Bescós-Atín, Coro
Keywords: Estomatologia
Malalties de la boca
Diòxid de carboni
Estudi de casos
Oral medicine
Mouth diseases
Carbon dioxide
Case studies
Issue Date: Jun-2015
Publisher: Elsevier
Abstract: The use of CO2 laser has become a routine procedure for the treatment of oral leukoplakia. In this retrospective study, we evaluated 65 patients with oral leukoplakia treated with CO2 laser vaporization. The main location was the tongue (n ¼ 21/65, 32.3%). The initial biopsy showed mild/moderate dysplasia in almost half the patients (n ¼ 29, 44.6%) and hyperplasia without dysplasia in around a third of the patients (n ¼ 21, 32.3%). The recurrence and malignant transformation rates were 33.8% (n ¼ 22) and 15.4% (n ¼ 10), respectively. The follow-up mean (standard deviation) was 15.0 (10.6) months. The procedure-related complications rate was 7.7% (n ¼ 5). The KaplaneMeier curves for time to recurrence showed differences only for gingiva lesions compared to tongue lesions (log rank, p ¼ 0.032). Malignant leukoplakia transformation is independent of treatment, although it seems advisable to treat leukoplakia with or without dysplasia.
Note: Versió postprint del document publicat a:
It is part of: Journal of Cranio-Maxillofacial Surgery, 2015, vol. 43, num. 5, p. 677-681
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ISSN: 1010-5182
Appears in Collections:Articles publicats en revistes (Odontostomatologia)

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