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Title: Influence of the IL17A locus in giant cell arteritis susceptibility
Author: Márquez, Ana
Hernández Rodríguez, José
Cid Xutglà, M. Cinta
Solans, Roser
Castañeda, Santos
Fernández-Contreras, M. E.
Ramentol, Marc
Morado, Inmaculada C.
Narváez García, Francisco Javier
Gómez Vaquero, Carmen
Martínez Taboada, Víctor Manuel
Ortego Centeno, Norberto
Sopeña, Bernardo
Monfort, Jordi
García-Villanueva, María Jesús
Caminal Montero, L.
Miguel, Eugenio de
Blanco, Ricardo
Spanish GCA Consortium
Palm, Oyvind
Molberg, O.
Latus, J.
Braun, Niko
Moosig, Frank
Witte, Torsten
Beretta, Lorenzo
Santaniello, Alessandro
Pazzola, Giulia
Boiardi, Luigi
Salvarani, Carlo
González-Gay, Miguel A.
Martín, Javier
Keywords: Arteritis de cèl·lules gegants
Polimorfisme genètic
Giant cell arteritis
Genetic polymorphisms
Issue Date: Sep-2014
Publisher: BMJ Publishing Group
Abstract: Objective: Different lines of evidence have highlighted the role of IL-17A in the inflammatory process occurring in giant cell arteritis (GCA). The aim of the present study was to assess whether the IL17A locus influences GCA susceptibility and its clinical subphenotypes. Methods: We carried out a large meta-analysis including a total of 1266 biopsy-proven GCA patients and 3779 healthy controls from four European populations (Spain, Italy, Germany and Norway). Five IL17A polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909) were selected by tagging and genotyped using TaqMan assays. Allelic combination and dependency tests were also performed. Results: In the pooled analysis, two of the five analysed polymorphisms showed evidence of association with GCA (rs2275913: PMH=1.85E−03, OR=1.17 (1.06-1.29); rs7747909: PMH=8.49E-03, OR=1.15 (1.04-1.27)). A clear trend of association was also found for the rs4711998 variant (PMH=0.059, OR=1.11 (1.00-1.23)). An independent effect of rs2275913 and rs4711998 was evident by conditional regression analysis. In addition, the haplotype harbouring the risk alleles better explained the observed association than the polymorphisms independently (likelihood p value <10−05). Conclusions: Polymorphisms within the IL17A locus show a novel association with GCA. This finding supports the relevant role of the Th17 cells in this vasculitis pathophysiology.
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It is part of: Annals of the Rheumatic Diseases, 2014, vol. 73, num. 9, p. 1742-1745
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ISSN: 0003-4967
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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