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Title: Lung bioengineering: physical stimuli and stem/progenitor cell biology interplay towards biofabricating a functional organ
Author: Nonaka, Paula Naomi
Uriarte, Juan José
Campillo, Noelia
Oliveira, Vinicius R.
Navajas Navarro, Daniel
Farré Ventura, Ramon
Keywords: Bioenginyeria
Cèl·lules mare
Enginyeria biomèdica
Malalties dels pulmons
Stem cells
Biomedical engineering
Pulmonary diseases
Issue Date: 1-Nov-2016
Publisher: BioMed Central
Abstract: A current approach to obtain bioengineered lungs as a future alternative for transplantation is based on seeding stem cells on decellularized lung scaffolds. A fundamental question to be solved in this approach is how to drive stem cell differentiation onto the different lung cell phenotypes. Whereas the use of soluble factors as agents to modulate the fate of stem cells was established from an early stage of the research with this type of cells, it took longer to recognize that the physical microenvironment locally sensed by stem cells (e.g. substrate stiffness, 3D architecture, cyclic stretch, shear stress, air-liquid interface, oxygenation gradient) also contributes to their differentiation. The potential role played by physical stimuli would be particularly relevant in lung bioengineering since cells within the organ are physiologically subjected to two main stimuli required to facilitate efficient gas exchange: air ventilation and blood perfusion across the organ. The present review focuses on describing how the cell mechanical microenvironment can modulate stem cell differentiation and how these stimuli could be incorporated into lung bioreactors for optimizing organ bioengineering.
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It is part of: Respiratory Research, 2016, vol. 17, p. 161
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ISSN: 1465-993X
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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