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http://hdl.handle.net/2445/113202
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DC Field | Value | Language |
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dc.contributor.author | Bautista Rodríguez, Carles | - |
dc.contributor.author | Launes Montaña, Cristian | - |
dc.contributor.author | Jordán García, Iolanda | - |
dc.contributor.author | Andrés, Maria | - |
dc.contributor.author | Arias, Maria Teresa | - |
dc.contributor.author | Lozano Soto, Francisco | - |
dc.contributor.author | García García, Juan José | - |
dc.contributor.author | Muñoz-Almagro, Carmen | - |
dc.date.accessioned | 2017-07-03T06:34:16Z | - |
dc.date.available | 2017-07-03T06:34:16Z | - |
dc.date.issued | 2017-05-31 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/113202 | - |
dc.description.abstract | OBJECTIVES: The objective of this study was to evaluate to evaluate the role of mannose-binding-lectin deficient genotypes in pneumococcal meningitis (PM) in children. METHODS: We performed a 16-year retrospective study (January 2001 to March 2016) including patients ≤ 18 years with PM. Variables including attack rate of pneumococcal serotype (high or low invasive capacity) and MBL2 genotypes associated with low serum MBL levels were recorded. RESULTS: Forty-eight patients were included in the study. Median age was 18.5 months and 17/48 episodes (35.4%) occurred in children ≤ 12 months old. Serotypes with high-invasive disease potential were identified in 15/48 episodes (31.2%). MBL2 deficient genotypes accounted for 18.8% (9/48). Children ≤ 12 months old had a 7-fold risk (95% CI: 1.6-29.9; p < 0.01) of having a MBL2 deficient genotype in comparison to those > 12 months old. A sub-analysis of patients by age group revealed significant proportions of carriers of MBL2 deficient genotypes among those ≤ 12 months old with PM caused by opportunistic serotypes (54.5%), admitted to the PICU (Pediatric Intensive Care Unit) (46.7%) and of White ethnicity (35.7%). These proportions were significantly higher than in older children (all p<0.05). CONCLUSIONS: Our results suggest that differences in MBL2 genotype in children ≤12 months old affects susceptibility to PM, and it may have an important role in the episodes caused by non-high invasive disease potential serotypes. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0178377 | - |
dc.relation.ispartof | PLoS One, 2017, vol. 12, num. 5, p. e0178377 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0178377 | - |
dc.rights | cc-by (c) Bautista-Rodríguez, Carles et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Meningitis | - |
dc.subject.classification | Infeccions per pneumococs | - |
dc.subject.classification | Infants | - |
dc.subject.classification | Epidemiologia | - |
dc.subject.classification | Salut pública | - |
dc.subject.classification | Unitats de cures intensives | - |
dc.subject.other | Meningitis | - |
dc.subject.other | Pneumococcal Infections | - |
dc.subject.other | Children | - |
dc.subject.other | Epidemiology | - |
dc.subject.other | Public health | - |
dc.subject.other | Intensive care units | - |
dc.title | Mannose-binding lectin-deficient genotypes as a risk factor of pneumococcal meningitis in infants | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 672568 | - |
dc.date.updated | 2017-07-03T06:34:17Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28562692 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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672568.pdf | 825.83 kB | Adobe PDF | View/Open |
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