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http://hdl.handle.net/2445/113245
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DC Field | Value | Language |
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dc.contributor.author | Fenutría, Rafael | - |
dc.contributor.author | Martinez, Vanesa Gabriela | - |
dc.contributor.author | Simões, Inês | - |
dc.contributor.author | Postigo, Jorge | - |
dc.contributor.author | Gil, Victor | - |
dc.contributor.author | Martínez-Florensa, Mario | - |
dc.contributor.author | Sintes, Jordi | - |
dc.contributor.author | Naves, Rodrigo | - |
dc.contributor.author | Cashman, Kevin S. | - |
dc.contributor.author | Alberola-Ila, José | - |
dc.contributor.author | Ramos Casals, Manuel | - |
dc.contributor.author | Soldevila, Gloria | - |
dc.contributor.author | Raman, Chander | - |
dc.contributor.author | Merino, Jesús | - |
dc.contributor.author | Merino, Ramón | - |
dc.contributor.author | Engel Rocamora, Pablo | - |
dc.contributor.author | Lozano Soto, Francisco | - |
dc.date.accessioned | 2017-07-03T11:23:15Z | - |
dc.date.available | 2017-07-03T11:23:15Z | - |
dc.date.issued | 2014-01-15 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/113245 | - |
dc.description.abstract | CD5 is a lymphoid-specific transmembrane glycoprotein constitutively expressed on thymocytes and mature T and B1a lymphocytes. Current data support the view that CD5 is a negative regulator of antigen-specific receptor-mediated signaling in these cells, and that this would likely be achieved through interaction with CD5 ligand/s (CD5L) of still undefined nature expressed on immune or accessory cells. To determine the functional consequence of loss of CD5/CD5L interaction in vivo, a new transgenic mouse line was generated (shCD5EμTg), expressing a circulating soluble form of human CD5 (shCD5) as a decoy to impair membrane-bound CD5 function. These shCD5EμTg mice showed an enhanced response to autologous antigens, as deduced from the presentation of more severe forms of experimentally inducible autoimmune disease (collagen-induced arthritis, CIA; and experimental autoimmune encephalitis, EAE), as well as an increased anti-tumoral response in non-orthotopic cancer models (B16 melanoma). This enhancement of the immune response was in agreement with the finding of significantly reduced proportions of spleen and lymph node Treg cells (CD4+CD25+FoxP3+), and of peritoneal IL-10-producing and CD5+ B cells, as well as an increased proportion of spleen NKT cells in shCD5EμTg mice. Similar changes in lymphocyte subpopulations were observed in wild-type mice following repeated administration of exogenous recombinant shCD5 protein. These data reveal the relevant role played by CD5/CD5L interactions on the homeostasis of some functionally relevant lymphocyte subpopulations and the modulation of immune responses to autologous antigens. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0084895 | - |
dc.relation.ispartof | PLoS One, 2014, vol. 9, num. 1, p. e84895 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0084895 | - |
dc.rights | cc-by (c) Fenutría, Rafael et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Cèl·lules B | - |
dc.subject.classification | Cèl·lules T | - |
dc.subject.classification | Limfòcits | - |
dc.subject.classification | Antígens | - |
dc.subject.classification | Melsa | - |
dc.subject.classification | Resposta immunitària | - |
dc.subject.other | B cells | - |
dc.subject.other | T cells | - |
dc.subject.other | Lymphocytes | - |
dc.subject.other | Antigens | - |
dc.subject.other | Spleen | - |
dc.subject.other | Immune response | - |
dc.title | Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 647387 | - |
dc.date.updated | 2017-07-03T11:23:15Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 24454761 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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File | Description | Size | Format | |
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647387.pdf | 751 kB | Adobe PDF | View/Open |
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