Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/113435
Title: Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain
Author: Fernández de Larrea, Nerea
Michel, Angelika
Romero, Beatriz
Pérez Gómez, Beatriz
Moreno Aguado, Víctor
Martín, Vicente
Dierssen-Sotos, Trinidad
Jiménez Moleón, José J.
Castilla, Jesús
Tardón, Adonina
Ruiz, Irune
Peiró, Rosana
Tejada, Antonio
Chirlaque, María Dolores
Butt, Julia A.
Olmedo Requena, Rocío
Gómez Acebo, Inés
Linares, Pedro
Boldo, Elena
Castells Garangou, Antoni
Pawlita, Michael
Castaño Vinyals, Gemma
Kogevinas, Manolis
Sanjosé Llongueras, Silvia de
Pollán, Marina
Campo, Rosa del
Waterboer, Tim
Aragonés, Nuria
Keywords: Helicobacter pylori
Càncer colorectal
Helicobacter pylori
Colorectal cancer
Issue Date: 29-May-2017
Publisher: Frontiers Research Foundation
Abstract: Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain. Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to >/=4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results:H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cagdelta showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women. Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3389/fmicb.2017.00888
It is part of: Frontiers in Microbiology, 2017, vol. 8, num. , p. 888
Related resource: http://dx.doi.org/10.3389/fmicb.2017.00888
URI: http://hdl.handle.net/2445/113435
ISSN: 1664-302X
Appears in Collections:Articles publicats en revistes (ISGlobal)

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