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Title: Urinary Arsenic Speciation in Children and Pregnant Women from Spain
Author: Signes Pastor, Antonio J.
Carey, Manus
Vioque, Jesus
Navarrete Muñoz, Eva Maria
Rodríguez Dehli, Cristina
Tardón, Adonina
Zubero, Begoña
Santa Marina, Loreto
Vrijheid, Martine
Casas, Maribel
Llop, Sabrina
Gonzalez Palacios, Sandra
Meharg, Andrew A.
Keywords: Embaràs
Pregnant women
Issue Date: 12-Aug-2016
Publisher: Springer
Abstract: Inorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero and early-life exposure, even low to moderate levels of i-As, may have a marked effect throughout the lifespan. Ion chromatography-mass spectrometry detection (IC-ICP-MS) was used to analyse urinary arsenic speciation, as an exposure biomarker, in samples of 4-year-old children with relatively low-level arsenic exposure living in different regions in Spain including Asturias, Gipuzkoa, Sabadell and Valencia. The profile of arsenic metabolites in urine was also determined in samples taken during pregnancy (1st trimester) and in the children from Valencia of 7 years old. The median of the main arsenic species found in the 4-year-old children was 9.71 mug/l (arsenobetaine-AsB), 3.97 mug/l (dimethylarsinic acid-DMA), 0.44 mug/l (monomethylarsonic acid-MMA) and 0.35 mug/l (i-As). Statistically significant differences were found in urinary AsB, MMA and i-As according to the study regions in the 4-year-old, and also in DMA among pregnant women and their children. Spearman's correlation coefficient among urinary arsenic metabolites was calculated, and, in general, a strong methylation capacity to methylate i-As to MMA was observed.
Note: Reproducció del document publicat a:
It is part of: Exposure & Health, 2017, vol. 9, num. 2, p. 105-111
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ISSN: 2451-9766
Appears in Collections:Articles publicats en revistes (ISGlobal)

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