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Title: Structural integrity of the contralesional hemisphere predicts cognitive impairment in chronic stroke
Author: Dacosta Aguayo, Rosalia
Graña, Manuel
Fernández-Andújar, Marina
López Cancio, Elena
Cáceres, Cynthia
Bargalló Alabart, Núria
Barrios, Mayte
Clemente, Immaculada
Dávalos, Antoni
Auer, Tibor
Mataró Serrat, Maria
Keywords: Neuropsicologia
Lesions cerebrals
Tests neuropsicològics
Brain damage
Neuropsychological tests
Issue Date: 2014
Publisher: Public Library of Science (PLoS)
Abstract: After stroke, white matter integrity can be affected both locally and distally to the primary lesion location. It has been shown that tract disruption in mirror's regions of the contralateral hemisphere is associated with degree of functional impairment. Fourteen patients suffering right hemispheric focal stroke (S) and eighteen healthy controls (HC) underwent Diffusion Weighted Imaging (DWI) and neuropsychological assessment. The stroke patient group was divided into poor (SP; n = 8) and good (SG; n = 6) cognitive recovery groups according to their cognitive improvement from the acute phase (72 hours after stroke) to the subacute phase (3 months post-stroke). Whole-brain DWI data analysis was performed by computing Diffusion Tensor Imaging (DTI) followed by Tract Based Spatial Statistics (TBSS). Assessment of effects was obtained computing the correlation of the projections on TBSS skeleton of Fractional Anisotropy (FA) and Radial Diffusivity (RD) with cognitive test results. Significant decrease of FA was found only in right brain anatomical areas for the S group when compared to the HC group. Analyzed separately, stroke patients with poor cognitive recovery showed additional significant FA decrease in several left hemisphere regions; whereas SG patients showed significant decrease only in the left genu of corpus callosum when compared to the HC. For the SG group, whole brain analysis revealed significant correlation between the performance in the Semantic Fluency test and the FA in the right hemisphere as well as between the performance in the Grooved Pegboard Test (GPT) and theTrail Making Test-part A and the FA in the left hemisphere. For the SP group, correlation analysis revealed significant correlation between the performance in the GPT and the FA in the right hemisphere.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2014, vol. 9, num. 1, p. 1-11
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa)
Articles publicats en revistes (Psicologia Clínica i Psicobiologia)

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