Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/113704
Title: The Relationship Between Dehydroepiandrosterone (DHEA), Working Memory and Distraction - a Behavioral and Electrophysiological Approach
Author: do Vale, Sónia
Selinger, Lenka
Martins Martin, João
Coelho Gomes, Ana
Bicho, Manuel
do Carmo, Isabel
Escera i Micó, Carles
Keywords: Hidrocortisona
Visió
Cognició
Memòria
Estrès (Psicologia)
Hydrocortisone
Visión
Cognition
Memory
Stress (Psychology)
Issue Date: 2014
Publisher: Public Library of Science (PLoS)
Abstract: Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEAS) have been reported to have memory enhancement effects in humans. A neuro-stimulatory action and an anti-cortisol mechanism of action may contribute to that relation. In order to study DHEA, DHEAS and cortisol relations to working memory and distraction, we recorded the electroencephalogram of 23 young women performing a discrimination (no working memory load) or 1-back (working memory load) task in an audio-visual oddball paradigm. We measured salivary DHEA, DHEAS and cortisol both before each task and at 30 and 60 min. Under working memory load, a higher baseline cortisol/DHEA ratio was related to higher distraction as indexed by an enhanced novelty P3. This suggests that cortisol may lead to increased distraction whereas DHEA may hinder distraction by leading to less processing of the distractor. An increased DHEA production with consecutive cognitive tasks was found and higher DHEA responses attributed to working memory load were related to enhanced working memory processing as indexed by an enhanced visual P300. Overall, the results suggest that in women DHEA may oppose cortisol effects reducing distraction and that a higher DHEA response may enhance working memory at the electrophysiological level.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0104869
It is part of: PLoS One, 2014, vol. 9, num. 8
Related resource: https://doi.org/10.1371/journal.pone.0104869
URI: http://hdl.handle.net/2445/113704
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Psicologia Clínica i Psicobiologia)

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