Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/113706
Title: Causes of death in a contemporary cohort of patients with invasive aspergillosis
Author: Garcia Vidal, Carolina
Peghin, Maddalena
Cervera, Carlos
Gudiol González, Carlota
Ruiz, Isabel (Ruiz Camps)
Moreno Camacho, Ma. Asunción
Royo-Cebrecos, Cristina
Roselló, Eva
Puig de la Bellacasa, Jordi
Ayats, Josefina
Carratalà, Jordi
Keywords: Infeccions respiratòries
Pacients
Malalties del fetge
Causes de la mort
Aspergil·losi
Respiratory infections
Patients
Liver diseases
Causes of death
Aspergillosis
Issue Date: 24-Mar-2015
Publisher: Public Library of Science (PLoS)
Abstract: Information regarding the processes leading to death in patients with invasive aspergillosis (IA) is lacking. We sought to determine the causes of death in these patients, the role that IA played in the cause, and the timing of death. The factors associated with IA-related mortality are also analyzed. We conducted a multicenter study (2008-2011) of cases of proven and probable IA. The causes of death and whether mortality was judged to be IA-related or IA-unrelated were determined by consensus using a six-member review panel. A multivariate analysis was performed to determine risk factors for IA-related death. Of 152 patients with IA, 92 (60.5%) died. Mortality was judged to be IA-related in 62 cases and IA-unrelated in 30. The most common cause of IA-related death was respiratory failure (50/62 patients), caused primarily by Aspergillus infection, although also by concomitant infections or severe comorbidities. Progression of underlying disease and bacteremic shock were the most frequent causes of IA-unrelated death. IA-related mortality accounted for 98% and 87% of deaths within the first 14 and 21 days, respectively. Liver disease (HR 4.54; 95% CI, 1.69-12.23) was independently associated with IA-related mortality, whereas voriconazole treatment was associated with reduced risk of death (HR 0.43; 95% CI, 0.20-0.93). In conclusion, better management of lung injury after IA diagnosis is the main challenge for physicians to improve IA outcomes. There are significant differences in causes and timing between IA-related and IA-unrelated mortality and these should be considered in future research to assess the quality of IA care
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0120370
It is part of: PLoS One, 2015, vol. 10, num. 3, p. e0120370
Related resource: https://doi.org/10.1371/journal.pone.0120370
URI: http://hdl.handle.net/2445/113706
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Medicina)

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