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Title: Immunodiagnostic tests' predictive values for progression to tuberculosis in transplant recipients. A prospective cohort study
Author: Muñoz, Laura
Gomila, Aina
Casas, Susana
Castellote, José
Arnan, Montserrat
Rafecas Renau, Antonio
Santín Cerezales, Miguel
Keywords: Diagnòstic immunològic
Trasplantament hepàtic
Diagnostic immunohistochemistry
Hepatic transplantation
Issue Date: Apr-2015
Publisher: Wolters Kluwer Health
Abstract: Background: Little is known about the predictive value for progression to tuberculosis (TB) of interferon-γ release assays and how they compare with the tuberculin skin test (TST) in assessing the risk of TB infection in transplant recipients. Methods: We screened 50 liver transplant (LT) and 26 hematopoietic stem cell transplant (HSCT) recipients with both QuantiFERON-TB Gold In-tube (QFT-GT) and TST and prospectively followed them for a median of 47 months without preventive chemoprophylaxis. Results: In the LT cohort, 1 in 22 (4.5%) QFT-GT-positive patients developed posttransplant TB, compared with none of the QFT-GT-negative patients. In the HSCT cohort, none of the 7 QFT-GT-positive patients developed TB, whereas 1 case (5.3%) progressed to active TB among the 19 QFT-GT-negative patients. Comparable results were obtained with the TST: in the LT group, 1 of 23 TST-positive and none of the 27 TST-negative patients developed TB; and in the HSCT group, none of the 8 TST-positive and one of the 18 TST-negative patients progressed to active TB. Conclusions: In this cohort of transplant recipients, the positive predictive value of QFT-GT for progression to active TB was low and comparable to that of TST. Although the risk of developing TB in patients with negative results at baseline is very low, some cases may still occur.
Note: Reproducció del document publicat a:
It is part of: Transplantation Direct, 2015, vol. 1, num. 3, p. 1-5
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ISSN: 2373-8731
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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