Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/113887
Title: Dietary flavonoids, lignans and colorectal cancer prognosis
Author: Zamora-Ros, Raul
Guinó, Elisabet
Henar Alonso, M.
Vidal, Carmen
Barenys de Lacha, Mercé
Soriano, Antonio
Moreno Aguado, Víctor
Keywords: Flavonoides
Pronòstic mèdic
Càncer colorectal
Dieta
Flavonoids
Prognosis
Colorectal cancer
Diet
Issue Date: 15-Sep-2015
Publisher: Nature Publishing Group
Abstract: Flavonoids and lignans are polyphenol classes with anticarcinogenic activities against colorectal cancer (CRC). However, very limited epidemiological evidence exists on their effects on CRC prognosis. This study aimed to evaluate the association between flavonoid and lignan intakes with the risk of CRC recurrence and overall survival in CRC patients. The study followed incident histologically confirmed CRC cases in Barcelona (Spain). Validated dietary questionnaires and lifestyle information were collected at recruitment. An ad hoc food composition database on flavonoids and lignans was compiled by using data from the US Department of Agriculture and Phenol-Explorer databases. Adjusted hazards ratios (HR) and 95% confidence intervals (CIs) were estimated using multivariable Cox models. After 8.6 years of mean follow-up, 133 of 409 (32.5%) participants died and 77 of 319 (24.1%) had a CRC recurrence. Total flavonoids were associated neither with CRC recurrence (HR comparing extreme tertiles 1.13, 95% CI 0.64-2.02; P-trend 0.67) nor with overall survival (HR(T3vsT1) 1.06, 95% CI 0.69-1.65; P-trend 0.78) in the multivariable models. No associations were also observed with either total lignans or any flavonoid subclass intake. In conclusion, the results of the current study do not support a role of flavonoid and lignan intake in the CRC prognosis.
Note: Reproducció del document publicat a: https://doi.org/10.1038/srep14148
It is part of: Scientific Reports, 2015, vol. 5, p. 14148
Related resource: https://doi.org/10.1038/srep14148
URI: http://hdl.handle.net/2445/113887
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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