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Title: High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides
Author: Gamba, Ilaria
Salvadó, Iria
Brissos, Rosa F.
Gámez Enamorado, Patrick
Brea, José
Loza, María Isabel
Vázquez, M. Eugenio
Vázquez López, Miguel
Keywords: Síntesi de pèptids
Física de l'estat sòlid
Peptide synthesis
Solid state physics
Issue Date: 21-Jan-2016
Publisher: Royal Society of Chemistry
Abstract: We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell lines.
Note: Versió postprint del document publicat a:
It is part of: Chemical Communications, 2016, vol. 52, num. 6, p. 1234-1237
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ISSN: 1359-7345
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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