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http://hdl.handle.net/2445/114162
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DC Field | Value | Language |
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dc.contributor.author | Gamba, Ilaria | - |
dc.contributor.author | Salvadó, Iria | - |
dc.contributor.author | Brissos, Rosa F. | - |
dc.contributor.author | Gámez Enamorado, Patrick | - |
dc.contributor.author | Brea, José | - |
dc.contributor.author | Loza, María Isabel | - |
dc.contributor.author | Vázquez, M. Eugenio | - |
dc.contributor.author | Vázquez López, Miguel | - |
dc.date.accessioned | 2017-07-21T07:23:43Z | - |
dc.date.available | 2017-07-21T07:23:43Z | - |
dc.date.issued | 2016-01-21 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.uri | http://hdl.handle.net/2445/114162 | - |
dc.description.abstract | We demonstrate the application of solid-phase peptide synthesis methods for the straightforward assembly of polynuclear Ir(III) organometallopeptides, and show that their oligoarginine derivatives exhibit high DNA binding affinity, sequence selectivity, and high cytotoxicity towards a set of cancer cell lines. | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Royal Society of Chemistry | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1039/C5CC07619F | - |
dc.relation.ispartof | Chemical Communications, 2016, vol. 52, num. 6, p. 1234-1237 | - |
dc.relation.uri | https://doi.org/10.1039/C5CC07619F | - |
dc.rights | (c) Gamba, Ilaria et al., 2016 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Síntesi de pèptids | - |
dc.subject.classification | Física de l'estat sòlid | - |
dc.subject.classification | ADN | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Peptide synthesis | - |
dc.subject.other | Solid state physics | - |
dc.subject.other | DNA | - |
dc.subject.other | Cancer | - |
dc.title | High-affinity sequence-selective DNA binding by iridium(III) polypyridyl organometallopeptides | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 656122 | - |
dc.date.updated | 2017-07-21T07:23:43Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/340055/EU//METBIOCAT | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26611126 | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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656122.pdf | 2.82 MB | Adobe PDF | View/Open |
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