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Title: Respiratory microbiota and lower respiratory tract disease
Author: Lanaspa, Miguel
Bassat Orellana, Quique
Medeiros, Marcia Melo
Muñoz-Almagro, Carmen
Keywords: Malalties de l'aparell respiratori
Respiratory diseases
Issue Date: 7-Jul-2017
Publisher: Taylor & Francis
Abstract: INTRODUCTION: The respiratory airways harbor a complex succession of ecological niches with distinct but related bacterial communities. Particular challenges of respiratory microbiome research have led to limited scientific output compared to other human microbiomes. Areas covered: In this review, we summarize the current state of knowledge of the bacterial respiratory microbiome, with a particular focus on associations between the respiratory microbiome and lower respiratory tract conditions. Expert commentary: There is growing evidence that the respiratory microbiome is associated with lower respiratory infectious diseases and related conditions. Most respiratory microbiome reports are metataxonomic cross-sectional or case-control studies with relatively small sample sizes. Large, prospective projects with metatranscriptomics or metabolomics approach are needed to unravel the effect of the respiratory microbiome on health-related conditions. Moreover, standardization in sampling, library preparation, sequencing techniques and data analysis should be encouraged.
Note: Reproducció del document publicat a:
It is part of: Expert Review of Anti-Infective Therapy, 2017, vol. 15, num. 7, p. 703-711
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ISSN: 1478-7210
Appears in Collections:Articles publicats en revistes (ISGlobal)

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