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Title: Gene-wide Association Study Reveals RNF122 Ubiquitin Ligase as a Novel Susceptibility Gene for Attention Deficit Hyperactivity Disorder
Author: García Martínez, Iris
Sánchez Mora, Cristina
Soler Artigas, Maria
Rovira, Paula
Pagerols, Mireia
Corrales, Montse
Calvo Sánchez, Eva
Richarte, Vanesa
Bustamante Pineda, Mariona
Sunyer Deu, Jordi
Cormand Rifà, Bru
Casas, Miquel
Ramos Quiroga, Josep Antoni
Ribasés Haro, Marta
Keywords: Trastorns per dèficit d'atenció amb hiperactivitat en els infants
Genètica humana
Attention deficit disorder with hyperactivity in children
Human genetics
Issue Date: 14-Jul-2017
Publisher: Nature Publishing Group
Abstract: Attention Deficit Hyperactivity Disorder (ADHD) is a common childhood-onset neurodevelopmental condition characterized by pervasive impairment of attention, hyperactivity, and/or impulsivity that can persist into adulthood. The aetiology of ADHD is complex and multifactorial and, despite the wealth of evidence for its high heritability, genetic studies have provided modest evidence for the involvement of specific genes and have failed to identify consistent and replicable results. Due to the lack of robust findings, we performed gene-wide and pathway enrichment analyses using pre-existing GWAS data from 607 persistent ADHD subjects and 584 controls, produced by our group. Subsequently, expression profiles of genes surpassing a follow-up threshold of P-value < 1e-03 in the gene-wide analyses were tested in peripheral blood mononucleated cells (PBMCs) of 45 medication-naive adults with ADHD and 39 healthy unrelated controls. We found preliminary evidence for genetic association between RNF122 and ADHD and for its overexpression in adults with ADHD. RNF122 encodes for an E3 ubiquitin ligase involved in the proteasome-mediated processing, trafficking, and degradation of proteins that acts as an essential mediator of the substrate specificity of ubiquitin ligation. Thus, our findings support previous data that place the ubiquitin-proteasome system as a promising candidate for its involvement in the aetiology of ADHD.
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It is part of: Scientific Reports, 2017, vol. 7, num. 1, p. 5407
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (ISGlobal)

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