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Title: Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer
Author: Royo, Felix
Zúñiga García, Patricia
Torrano, Verónica
Loizaga-Iriarte, Ana
Sanchez-Mosquera, Pilar
Ugalde-Olano, Aitziber
González, Esperanza
Cortazar, Ana Rosa
Palomo, Laura
Fernández-Ruiz, Sonia
Lacasa-Viscasillas, Isabel
Berdasco, María
Sutherland, James David
Barrio, Rosa
Zabala Letona, Amaia
Martín-Martín, Natalia
Arruabarrena-Aristorena, Amaia
Valcarcel-Jimenez, Lorea
Caro Maldonado, Alfredo
Gonzalez-Tampan, Jorge
Cachi-Fuentes, Guido
Esteller, Manel
Aransay, Ana Maria
Unda Urzaiz, Miguel
Falcón-Pérez, Juan M.
Carracedo, Arkaitz
Keywords: Càncer de pròstata
Malalties de la pròstata
Marcadors tumorals
Marcadors bioquímics
Anàlisi d'orina
Prostate cancer
Prostatic diseases
Tumor markers
Biochemical markers
Urine analysis
Issue Date: 12-Jan-2016
Publisher: Impact Journals
Abstract: Extracellular vesicles (EV) are emerging structures with promising properties for intercellular communication. In addition, the characterization of EV in biofluids is an attractive source of non-invasive diagnostic, prognostic and predictive biomarkers. Here we show that urinary EV (uEV) from prostate cancer (PCa) patients exhibit genuine and differential physical and biological properties compared to benign prostate hyperplasia (BPH). Importantly, transcriptomics characterization of uEVs led us to define the decreased abundance of Cadherin 3, type 1 (CDH3) transcript in uEV from PCa patients. Tissue and cell line analysis strongly suggested that the status of CDH3 in uEVs is a distal reflection of changes in the expression of this cadherin in the prostate tumor. CDH3 was negatively regulated at the genomic, transcriptional, and epigenetic level in PCa. Our results reveal that uEVs could represent a non-invasive tool to inform about the molecular alterations in PCa.
Note: Reproducció del document publicat a:
It is part of: Oncotarget, 2016, vol. 7, num. 6, p. 6835-6846
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ISSN: 1949-2553
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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