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Title: Dialkylammonium tert-Butylmethylphosphinites: Stable Intermediates for the Synthesis of P-Stereogenic Ligands
Author: Salomó i Prat, Ernest
Prades, Amparo
Riera i Escalé, Antoni
Verdaguer i Espaulella, Xavier
Keywords: Lligands (Bioquímica)
Compostos fosforosos
Catàlisi asimètrica
Ligands (Biochemistry)
Phosphorus compounds
Enantioselective catalysis
Issue Date: 22-Jun-2017
Publisher: American Chemical Society
Abstract: The preparation of shelf-stable crystalline salts of tert-butylmethylphosphinous acid borane 1 is described. X-ray analysis of diisopropylammonium tert-butylmethylphosphinite borane 4 revealed the existence of a cyclic hydrogen-bond network in the solid state which accounts for the increased melting point and stability. Dialkylammonium phosphinite boranes are convenient precursors of the chiral tert-butylmethylphosphine fragment. Compound 4 can be directly employed in SN2@P reactions with different nucleophiles to yield valuable P-stereogenic intermediates and ligands.
Note: Versió postprint del document publicat a:
It is part of: Journal of Organic Chemistry, 2017
Related resource:
ISSN: 0022-3263
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))
Articles publicats en revistes (Química Inorgànica i Orgànica)

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