Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/115326
Title: The International College of Neuropsychopharmacology (CINP) treatment guidelines for bipolar disorder in adults (CINP-BD-2017), part 4: Unmet needs in the treatment of Bipolar disorder and recommendations for future research
Author: Fountoulakis, Konstantinos N.
Vieta i Pascual, Eduard, 1963-
Young, Allan
Yatham, Lakshmi
Grunze, Heinz
Blier, Pierre
Moeller, Hans J.
Kasper, Siegfried
Keywords: Trastorn bipolar
Adults
Farmacologia
Manic-depressive illness
Adulthood
Pharmacology
Issue Date: 27-Sep-2016
Publisher: Oxford University Press
Abstract: Background: The current fourth paper on the International College of Neuropsychopharmacology guidelines for the treatment of bipolar disorder reports on the unmet needs that became apparent after an extensive review of the literature and also serves as a conclusion to the project of the International College of Neuropsychopharmacology workgroup. Materials and Methods: The systematic review of the literature that was performed to develop the International College of Neuropsychopharmacology guidelines for bipolar disorder identified and classified a number of potential shortcomings. Results: Problems identified concerned the reliability and validity of the diagnosis of bipolar disorder and especially of bipolar depression. This, in turn, has profound consequences for early detection and correct treatment of the disorder. Another area that needs improvement is the unsatisfactory efficacy and effectiveness of therapeutic options, especially in special populations such as those with mixed features and rapid cycling course. Gender issues and adherence problems constitute an additional challenge. The literature suggests that while treatment providers are concerned more with treatment-related issues, patients and their caregivers worry more about issues pertaining to the availability of services and care, quality of life, and various types of burden. The workgroup identified additional unmet needs related to the current standard of research in bipolar disorder. These include the fragmentation of bipolar disorder into phases that are handled as being almost absolutely independent from each other, and thus the development of an overall therapeutic strategy on the basis of the existing evidence is very difficult. Trials are not always designed in a way that outcomes cover the most important aspects of bipolar disorder, and often the reporting of the results is biased and unsatisfactory. The data on combination treatments and high dosages are sparse, whereas they are common in real world practice. Conclusions: The workgroup endorses the full release of raw study data to the scientific community, and the development of uniform clinical trial standards (also including more realistic outcomes) and the reporting of results. The 2 large appendices summarize the results of this systematic review with regard to the areas of lack of knowledge where further focused research is necessary.
Note: Podeu consultar la part 1: http://hdl.handle.net/2445/114765
Podeu consultar la part 2: http://hdl.handle.net/2445/114773
Podeu consultar la part 3: http://hdl.handle.net/2445/112428
Note: Reproducció del document publicat a: https://doi.org/10.1093/ijnp/pyw072
It is part of: International Journal of Neuropsychopharmacology, 2017, vol. 20, num. 2, p. 196-205
Related resource: https://doi.org/10.1093/ijnp/pyw072
http://hdl.handle.net/2445/114765
http://hdl.handle.net/2445/114773
http://hdl.handle.net/2445/112428
URI: http://hdl.handle.net/2445/115326
ISSN: 1461-1457
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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