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Title: Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons
Author: Martín Ibáñez, Raquel
Pardo Muñoz, Mònica
Giralt Torroella, Albert
Miguez, Andrés
Guardia, Inés
Marion Poll, Lucile
Herranz, Cristina
Esgleas, Miriam
García-Díaz Barriga, Gerardo
Edel, Michael John
Vicario Abejón, Carlos
Alberch i Vié, Jordi
Girault, Jean Antoine
Chan, Susan
Kastner, Philippe
Canals i Coll, Josep M.
Keywords: Cicle cel·lular
Mort cel·lular
Cell cycle
Cell death
Issue Date: 13-Mar-2017
Publisher: The Company of Biologists
Abstract: Here we unravel the mechanism of action of Helios (He) during the development of striatal medium spiny neurons (MSNs). He regulates the second wave of striatal neurogenesis involved in the generation of striatopallidal neurons that express dopamine 2 receptor (D2R) and enkephalin (ENK). To exert this effect He is expressed in neural progenitor cells (NPCs) retaining them into the G1/G0 phase of the cell cycle. Thus, the lack of He produces an increase of S-phase entry and S-phase length of NPCs which in turn impairs striatal neurogenesis and produces an accumulation of the number of cycling NPCs in the germinal zone (GZ) that end up dying at postnatal stages. Therefore, He-/- mice show a reduction in the number of Dorso-Medial Striatal MSNs in the adulthood that produces deficits in motor skills acquisition. In addition, overexpression of He in NPCs induce DARPP32 phenotype when transplanted in mouse striatum.Present findings demonstrate that He is involved in the correct development of a subset of striatopallidal MSNs and reveal new cellular mechanisms for neuronal development.
Note: Reproducció del document publicat a:
It is part of: Development, 2017, vol. 144, num. 8, p. 1566-1577
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ISSN: 0950-1991
Appears in Collections:Articles publicats en revistes (Biomedicina)

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