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Title: Genetic and functional characterization of disease associations explains comorbidity
Author: Rubio Perez, Carlota
Guney, Emre
Aguilar, Daniel
Piñero, Janet
Garcia Garcia, Javier
Iadarola, Barbara
Sanz, Ferran
Fernandez Fuentes, Narcís
Furlong, Laura I.
Oliva, Baldomero
Keywords: Comorbiditat
Genètica humana
Human genetics
Issue Date: 24-Jul-2017
Publisher: Nature Publishing Group
Abstract: Understanding relationships between diseases, such as comorbidities, has important socio-economic implications, ranging from clinical study design to health care planning. Most studies characterize disease comorbidity using shared genetic origins, ignoring pathway-based commonalities between diseases. In this study, we define the disease pathways using an interactome-based extension of known disease-genes and introduce several measures of functional overlap. The analysis reveals 206 significant links among 94 diseases, giving rise to a highly clustered disease association network. We observe that around 95% of the links in the disease network, though not identified by genetic overlap, are discovered by functional overlap. This disease network portraits rheumatoid arthritis, asthma, atherosclerosis, pulmonary diseases and Crohn's disease as hubs and thus pointing to common inflammatory processes underlying disease pathophysiology. We identify several described associations such as the inverse comorbidity relationship between Alzheimer's disease and neoplasms. Furthermore, we investigate the disruptions in protein interactions by mapping mutations onto the domains involved in the interaction, suggesting hypotheses on the causal link between diseases. Finally, we provide several proof-of-principle examples in which we model the effect of the mutation and the change of the association strength, which could explain the observed comorbidity between diseases caused by the same genetic alterations.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2017, vol. 7, num. 1, p. 6207
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (ISGlobal)

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