Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/116227
Title: | RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T Cell Responses in a Pediatric African Phase III Trial |
Author: | Moncunill, Gemma Rosa, Stephen C. de Ayestaran, Aintzane Nhabomba, Augusto J. Mpina, Maximilian Cohen, Kristen W. Jairoce, Chenjerai Rutishauser, Tobias Campo, Joseph J. Harezlak, Jaroslaw Sanz Ródenas, Héctor Díez-Padrisa, Núria Williams, Nana Aba Morris, Daryl Aponte, John J. Valim, Clarissa Daubenberger, Claudia Dobaño, Carlota, 1969- McElrath, M.Juliana |
Keywords: | Malària Plasmodium falciparum Àfrica Malaria Plasmodium falciparum Africa |
Issue Date: | 23-Aug-2017 |
Publisher: | Frontiers Media |
Abstract: | Comprehensive assessment of cellular responses to the RTS,S/AS01E vaccine is needed to understand potential correlates and ultimately mechanisms of protection against malaria disease. Cellular responses recognizing the RTS,S/AS01E-containing circumsporozoite protein (CSP) and Hepatitis B surface antigen (HBsAg) were assessed before and 1 month after primary vaccination by intracellular cytokine staining and 16-color flow cytometry in 105 RTS,S/AS01-vaccinated and 74 rabies-vaccinated participants (controls) in a pediatric phase III trial in Africa. RTS,S/AS01E-vaccinated children had significantly higher frequencies of CSP- and HBsAg-specific CD4+ T cells producing IL-2, TNF-alpha, and CD40L and HBsAg-specific CD4+ T producing IFN-gamma and IL-17 than baseline and the control group. Vaccine-induced responses were identified in both central and effector memory (EM) compartments. EM CD4+ T cells expressing IL-4 and IL-21 were detected recognizing both vaccine antigens. Consistently higher response rates to both antigens in RTS,S/AS01E-vaccinated than comparator-vaccinated children were observed. RTS,S/AS01E induced polyfunctional CSP- and HBsAg-specific CD4+ T cells, with a greater degree of polyfunctionality in HBsAg responses. In conclusion, RTS,S/AS01E vaccine induces T cells of higher functional heterogeneity and polyfunctionality than previously characterized. Responses detected in memory CD4+ T cell compartments may provide correlates of RTS,S/AS01-induced immunity and duration of protection in future correlates of immunity studies. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.3389/fimmu.2017.01008 |
It is part of: | Frontiers in Immunology, 2017, vol. 8, p. 1008 |
URI: | http://hdl.handle.net/2445/116227 |
Related resource: | http://dx.doi.org/10.3389/fimmu.2017.01008 |
ISSN: | 1664-3224 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
moncunill2017_2684.pdf | 4.32 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License