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http://hdl.handle.net/2445/116287
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DC Field | Value | Language |
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dc.contributor.author | Mas-Stachurska, Aleksandra | - |
dc.contributor.author | Siegert, Anna-Maria Elisa | - |
dc.contributor.author | Batlle, Montserrat | - |
dc.contributor.author | Gorbenko del Blanco, Darya | - |
dc.contributor.author | Meirelles, Thayna | - |
dc.contributor.author | Rubies, Cira | - |
dc.contributor.author | Bonorino, Fabio | - |
dc.contributor.author | Serra-Peinado, Carla | - |
dc.contributor.author | Bijnens, Bart | - |
dc.contributor.author | Baudin, Julio | - |
dc.contributor.author | Sitges Carreño, Marta | - |
dc.contributor.author | Mont Girbau, Lluís | - |
dc.contributor.author | Guasch i Casany, Eduard | - |
dc.contributor.author | Egea Guri, Gustavo | - |
dc.date.accessioned | 2017-10-06T16:33:14Z | - |
dc.date.available | 2017-10-06T16:33:14Z | - |
dc.date.issued | 2017-09-25 | - |
dc.identifier.issn | 2047-9980 | - |
dc.identifier.uri | http://hdl.handle.net/2445/116287 | - |
dc.description.abstract | BACKGROUND: Marfan syndrome (MF) leads to aortic root dilatation and a predisposition to aortic dissection, mitral valve prolapse, and primary and secondary cardiomyopathy. Overall, regular physical exercise is recommended for a healthy lifestyle, but dynamic sports are strongly discouraged in MF patients. Nonetheless, evidence supporting this recommendation is lacking. Therefore, we studied the role of long-term dynamic exercise of moderate intensity on the MF cardiovascular phenotype. METHODS AND RESULTS: In a transgenic mouse model of MF (Fbn1C1039G/+), 4-month-old wild-type and MF mice were subjected to training on a treadmill for 5 months; sedentary littermates served as controls for each group. Aortic and cardiac remodeling was assessed by echocardiography and histology. The 4-month-old MF mice showed aortic root dilatation, elastic lamina rupture, and tunica media fibrosis, as well as cardiac hypertrophy, left ventricular fibrosis, and intramyocardial vessel remodeling. Over the 5-month experimental period, aortic root dilation rate was significantly greater in the sedentary MF group, compared with the wild-type group (∆mm, 0.27±0.07 versus 0.13±0.02, respectively). Exercise significantly blunted the aortic root dilation rate in MF mice compared with sedentary MF littermates (∆mm, 0.10±0.04 versus 0.27±0.07, respectively). However, these 2 groups were indistinguishable by aortic root stiffness, tunica media fibrosis, and elastic lamina ruptures. In MF mice, exercise also produced cardiac hypertrophy regression without changes in left ventricular fibrosis. CONCLUSIONS: Our results in a transgenic mouse model of MF indicate that moderate dynamic exercise mitigates the progression of the MF cardiovascular phenotype. | - |
dc.format.extent | 26 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1161/JAHA.117.006438 | - |
dc.relation.ispartof | Journal Of The American Heart Association, 2017, vol. 6, num. 9, p. e006438 | - |
dc.relation.uri | https://doi.org/10.1161/JAHA.117.006438 | - |
dc.rights | cc-by-nc (c) Mas-Stachurska, Aleksandra et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Malalties hereditàries | - |
dc.subject.classification | Exercici | - |
dc.subject.classification | Aneurismes aòrtics | - |
dc.subject.classification | Models animals en la investigació | - |
dc.subject.other | Genetic diseases | - |
dc.subject.other | Exercise | - |
dc.subject.other | Aortic aneurysms | - |
dc.subject.other | Animal models in research | - |
dc.title | Cardiovascular benefits of moderate exercise training in Marfan syndrome: Insights from an animal model. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 673623 | - |
dc.date.updated | 2017-10-06T16:33:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28947563 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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673623.pdf | 2.64 MB | Adobe PDF | View/Open |
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