Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/116524
Title: Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization
Author: Smith, Caren E
Coltell, Oscar
Sorlí, José V
Estruch Riba, Ramon
Martínez-González, Miguel Ángel, 1957-
Salas Salvadó, Jordi
Fitó, Montserrat
Arós, Fernando
Dashti, Hassan S
Lai, Chao Q
Miró, Leticia
Serra Majem, Lluís
Gómez Gracia, Enrique
Fiol Sala, Miquel
Ros Rahola, Emilio
Aslibekyan, Stella
Hidalgo, Bertha
Neuhouser, Marian L
Di, Chongzhi
Tucker, Katherine L
Arnett, Donna K
Ordovás, José M
Corella Piquer, Dolores
Keywords: Malalties cardiovasculars
Llet
Hàbits alimentaris
Cardiovascular diseases
Milk
Food habits
Issue Date: 14-Sep-2016
Publisher: Nature Publishing Group
Abstract: Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through Mendelian randomization. We meta-analytically (n ≤ 20,089) evaluated associations between a lactase persistence (LP) SNP, the minichromosome maintenance complex component 6 (MCM6)-rs3754686C>T (nonpersistence>persistence), dairy intake, and CVD biomarkers in American (Hispanics, African-American and Whites) and Mediterranean populations. Moreover, we analyzed longitudinal associations with milk, CVD and mortality in PREDIMED), a randomized Mediterranean diet (MedDiet) intervention trial (n = 7185). The MCM6-rs3754686/MCM6-rs309180 (as proxy), LP-allele (T) was strongly associated with higher milk intake, but inconsistently associated with glucose and lipids, and not associated with CVD or total mortality in the whole population. Heterogeneity analyses suggested some sex-specific associations. The T-allele was associated with higher CVD and mortality risk in women but not in men (P-sex interaction:0.005 and 0.032, respectively), mainly in the MedDiet group. However, milk intake was not associated with CVD biomarkers, CVD or mortality either generally or in sub-groups. Although MCM6-rs3754686 is a good milk intake proxy in these populations, attributing its associations with CVD and mortality in Mediterranean women to milk is unwarranted, as other factors limiting the assumption of causality in Mendelian randomization may exist.
Note: Reproducció del document publicat a: https://doi.org/10.1038/srep33188
It is part of: Scientific Reports, 2016, vol. 6, num. 33188
Related resource: https://doi.org/10.1038/srep33188
URI: http://hdl.handle.net/2445/116524
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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