Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/116933
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Martínez Cengotitabengoa, Mónica | - |
dc.contributor.author | MacDowell, Karina S. | - |
dc.contributor.author | Alberich, Susana | - |
dc.contributor.author | Díaz, FJ. | - |
dc.contributor.author | García Bueno, Borja | - |
dc.contributor.author | Rodriguez Jimenez, Roberto | - |
dc.contributor.author | Bioque Alcázar, Miquel | - |
dc.contributor.author | Berrocoso, Esther | - |
dc.contributor.author | Parellada, Mara | - |
dc.contributor.author | Lobo, Antonio | - |
dc.contributor.author | Saiz, Pilar A. | - |
dc.contributor.author | Matute, Carlos | - |
dc.contributor.author | Bernardo Arroyo, Miquel | - |
dc.contributor.author | González-Pinto, Ana | - |
dc.contributor.author | Leza, Juan Carlos | - |
dc.date.accessioned | 2017-10-23T13:32:32Z | - |
dc.date.available | 2017-10-23T13:32:32Z | - |
dc.date.issued | 2015-06-30 | - |
dc.identifier.issn | 0586-7614 | - |
dc.identifier.uri | http://hdl.handle.net/2445/116933 | - |
dc.description.abstract | Previous studies have indicated systemic deregulation of the proinflammatory or anti-inflammatory balance in individuals with first-episode psychosis (FEP) that persists 12 months later. To identify potential risk/protective factors and associations with symptom severity, we assessed possible changes in plasma levels of neurotrophins (brain-derived neurotrophic factor [BDNF] and nerve growth factor [NGF]) and their receptors in peripheral blood mononuclear cells (PBMCs). Expression of the 2 forms of BDNF receptors (active TrkB-FL and inactiveTrkB-T1) in PBMCs of FEP patients changed over time, TrkB-FL expression increasing by 1 year after diagnosis, while TrkB-T1 expression decreased. The TrkB-FL/TrkB-T1 ratio (hereafter FL/T1 ratio) increased during follow-up in the nonaffective psychosis group only, suggesting different underlying pathophysiological mechanisms in subgroups of FEP patients. Further, the expression of the main NGF receptor, TrkA, generally increased in patients at follow-up. After adjusting for potential confounders, baseline levels of inducible isoforms of nitric oxide synthase, cyclooxygenase, and nuclear transcription factor were significantly associated with the FL/T1 ratio, suggesting that more inflammation is associated with higher values of this ratio. Interestingly, the FL/T1 ratio might have a role as a predictor of functioning, a regression model of functioning at 1 year suggesting that the effect of the FL/T1 ratio at baseline on functioning at 1 year depended on whether patients were treated with antipsychotics. These findings may have translational relevance; specifically, it might be useful to assess the expression of TrkB receptor isoforms before initiating antipsychotic treatment in FEPs | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1093/schbul/sbv078 | - |
dc.relation.ispartof | Schizophrenia Bulletin, 2015, vol. 42, num. 1, p. 142-151 | - |
dc.relation.uri | https://doi.org/10.1093/schbul/sbv078 | - |
dc.rights | cc-by-nc-nd (c) Martínez-Cengotitabengoa, Mónica et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Psicosi | - |
dc.subject.classification | Trastorns afectius | - |
dc.subject.classification | Antipsicòtics | - |
dc.subject.classification | Farmacologia | - |
dc.subject.classification | Estudi de casos | - |
dc.subject.classification | Inflamació | - |
dc.subject.other | Psychoses | - |
dc.subject.other | Affective disorders | - |
dc.subject.other | Antipsychotic drugs | - |
dc.subject.other | Pharmacology | - |
dc.subject.other | Case studies | - |
dc.subject.other | Inflammation | - |
dc.title | BDNF and NGF signalling in early phases of psychosis: relationship with inflammation and response to antipsychotics after a 1 year | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 654433 | - |
dc.date.updated | 2017-10-23T13:32:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26130821 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
654433.pdf | 625.39 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License