Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/117486
Title: | Maternal and fetal genetic contribution to gestational weight gain |
Author: | Warrington, Nicole M. Richmond, Rebecca C. Fenstra, Bjarke Myhre, Ronny Gaillard, Romy Paternoster, Lavinia Wang, Carol A. Beaumont, Robin N. Das, Shikta Murcia, Mario Barton, Sheila J. Espinosa Cardiel, Ana Thiering, Elisabeth Atalay, Mustafa Pitkanen, Niina Ntalla, Ioanna Jonsson, Anna E. Freathy, Rachel M. Karhunen, Ville Tiesler, Carla M. T. Allard, Catherine Crawford, Andrew Ring, Susan M. Melbye, Mads Magnus, Per Rivadeneira, Fernando Skotte, Line Hansen, Torben Marsh, Julie A. Guxens, Mònica Holloway, John W. Grallert, Harald Jaddoe, Vincent W. Lowe, William L. Roumeliotaki, Theano Hattersley, Andrew T. Lindi, Virpi Pahkala, Katja Panoutsopoulou, Kalliope Standl, Marie Flexeder, Claudia Bouchard, Luigi Nohr, Ellen Aagard Marina, Loreto Santa Kogevinas, Manolis Niinikoski, Harri Dedoussis, George Heinrich, Joachim Reynolds, Rebecca M. Lakka, Timo Zeggini, Eleftheria Raitakari, Olli T. Chatzi, Leda Inskip, Hazel M. Bustamante Pineda, Mariona Hivert, Marie-France Jarvelin, Marjo-Riitta Sorensen, Thorkild I. A. Pennell, Craig E. Felix, Janine F. Jacobsson, Bo Geller, Frank Evans, David M. Lawlor, Debbie A. |
Keywords: | Genètica mèdica Pes corporal Embaràs Medical genetics Body weight Pregnancy |
Issue Date: | 9-Oct-2017 |
Publisher: | Nature Publishing Group |
Abstract: | BACKGROUND: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG. PARTICIPANTS AND METHODS: A genome-wide association study was used to identify maternal and fetal variants contributing to GWG in up to 10 543 mothers and 16 317 offspring of European origin, with replication in 10 660 mothers and 7561 offspring. Additional analyses determined the proportion of variability in GWG from maternal and fetal common genetic variants and the overlap of established genome-wide significant variants for phenotypes relevant to GWG (e.g. maternal BMI and glucose, birthweight). RESULTS: Approximately 20% of the variability in GWG was tagged by common maternal genetic variants, and the fetal genome made a surprisingly minor contribution to explaining variation in GWG. Variants near the Pregnancy Specific Beta-1-Glycoprotein 5 (PSG5) gene reached genome-wide significance (P=1.71 x 10-8) for total GWG in the offspring genome, but did not replicate. Some established variants associated with increased BMI, fasting glucose and type 2 diabetes were associated with lower early, and higher later GWG. Maternal variants related to higher systolic blood pressure were related to lower late GWG. Established maternal and fetal birthweight variants were largely unrelated to GWG. CONCLUSION: We found a modest contribution of maternal common variants to GWG and some overlap of maternal BMI, glucose and type 2 diabetes variants with GWG. These findings suggest that associations between GWG and later offspring/maternal outcomes may be due to the relationship of maternal BMI and diabetes with GWG.International Journal of Obesity accepted article preview online, 09 October 2017. doi:10.1038/ijo.2017.248. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1038/ijo.2017.248 |
It is part of: | International Journal of Obesity, 2017, vol. , num. , p. Ahead of print |
URI: | http://hdl.handle.net/2445/117486 |
Related resource: | http://dx.doi.org/10.1038/ijo.2017.248 |
ISSN: | 0307-0565 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
warrington2017_2725.pdf | 1.47 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License