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http://hdl.handle.net/2445/117632
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DC Field | Value | Language |
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dc.contributor.author | Mir Morro, Bartomeu | - |
dc.contributor.author | Serrano, Israel | - |
dc.contributor.author | Buitrago Ospina, Diana Camila | - |
dc.contributor.author | Orozco López, Modesto | - |
dc.contributor.author | Escaja Sánchez, Nuria | - |
dc.contributor.author | González, Carlos | - |
dc.date.accessioned | 2017-11-10T15:07:02Z | - |
dc.date.available | 2018-09-21T05:10:25Z | - |
dc.date.issued | 2017-09-21 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/2445/117632 | - |
dc.description.abstract | We report here the solution structure of several repetitive DNA sequences containing d(TCGTTCCGT) and related repeats. At physiological pH, these sequences fold into i-motif like quadruplexes in which every two repeats a globular structure is stabilized by two hemiprotonated C:C+ base pairs, flanked by two minor groove tetrads resulting from the association of G:C or G:T base pairs. The interaction between the minor groove tetrads and the nearby C:C+ base pairs affords a strong stabilization, which results in effective pHT values above 7.5. Longer sequences with more than two repeats are able to fold in tandem, forming a rosary bead-like structure. Bioinformatics analysis shows that these sequences are prevalent in the human genome, and are present in development-related genes. | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/jacs.7b07383 | - |
dc.relation.ispartof | Journal of the American Chemical Society, 2017, vol. 139, num. 40, p. 13985-13988 | - |
dc.relation.uri | https://doi.org/10.1021/jacs.7b07383 | - |
dc.rights | (c) American Chemical Society , 2017 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Oligonucleòtids | - |
dc.subject.classification | Cromosomes humans | - |
dc.subject.classification | Genètica humana | - |
dc.subject.other | Oligonucleotides | - |
dc.subject.other | Human chromosomes | - |
dc.subject.other | Human genetics | - |
dc.title | Prevalent sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 673637 | - |
dc.date.updated | 2017-11-10T15:07:02Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/676556/EU//MuG | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28933543 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
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673637.pdf | 11.94 MB | Adobe PDF | View/Open |
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