Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/118043
Title: Identification of sapovirus GV.2, astrovirus VA3 and novel anelloviruses in serum from patients with acute hepatitis of unknown aetiology.
Author: Gonzales-Gustavson, Eloy
Timoneda Solé, Natàlia
Fernandez-Cassi, X.
Caballero, A.
Abril Ferrando, Josep Francesc, 1970-
Buti, Maria
Rodriguez-Frias, Francisco
Gironès Llop, Rosina
Keywords: Virus
Hepatitis
Viruses
Hepatitis
Issue Date: 5-Oct-2017
Publisher: Public Library of Science (PLoS)
Abstract: Hepatitis is a general term meaning inflammation of the liver, which can be caused by a variety of viruses. However, a substantial number of cases remain with unknown aetiology. We analysed the serum of patients with clinical signs of hepatitis using a metagenomics approach to characterize their viral species composition. Four pools of patients with hepatitis without identified aetiological agents were evaluated. Additionally, one pool of patients with hepatitis E (HEV) and pools of healthy volunteers were included as controls. A high diversity of anelloviruses, including novel sequences, was found in pools from patients with hepatitis of unknown aetiology. Moreover, viruses recently associated with gastroenteritis as sapovirus GV.2 and astrovirus VA3 were also detected only in those pools. Besides, most of the HEV genome was recovered from the HEV pool. Finally, GB virus C and human endogenous retrovirus were found in the HEV and healthy pools. Our study provides an overview of the virome in serum from hepatitis patients suggesting a potential role of these viruses not previously described in cases of hepatitis. However, further epidemiologic studies are necessary to confirm their contribution to the development of hepatitis.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0185911
It is part of: PLoS One, 2017, vol. 12, num. 10, p. e0185911
URI: http://hdl.handle.net/2445/118043
Related resource: https://doi.org/10.1371/journal.pone.0185911
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

Files in This Item:
File Description SizeFormat 
674397.pdf4.49 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons