Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/118318
Title: | Engineered muscle tissues for disease modeling and drug screening applications |
Author: | Mohammandi, Mohammad Hossein Obregón, Raquel Ahadian, Samad Ramon Azcon, Javier Radisic, Milica |
Keywords: | Músculs Fisiologia experimental Muscles Experimental physiology |
Issue Date: | 1-Nov-2017 |
Publisher: | Bentham Science Publishers |
Abstract: | Animal models have been the main resources for drug discovery and prediction of drugs’ pharmacokinetic responses in the body. However, noticeable drawbacks associated with animal models include high cost, low reproducibility, low physiological similarity to humans, and ethical problems. Engineered tissue models have recently emerged as an alternative or substitute for animal models in drug discovery and testing and disease modeling. In this review, we focus on skeletal muscle and cardiac muscle tissues by first describing their characterization and physiology. Major fabrication technologies (i.e., electrospinning, bioprinting, dielectrophoresis, textile technology, and microfluidics) to make functional muscle tissues are then described. Finally, currently used muscle tissue models in drug screening are reviewed and discussed |
Note: | Versió postprint del document publicat a: http://dx.doi.org/10.2174/1381612823666170215115445 |
It is part of: | Current Pharmaceutical Design, 2017, vol. 23, p. 2991-3004 |
URI: | http://hdl.handle.net/2445/118318 |
DOI: | http://dx.doi.org/10.2174/1381612823666170215115445 |
ISSN: | 1381-6128 |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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L25_2017_Current Pharmaceutical Design_23_2991_OA.pdf | 1.42 MB | Adobe PDF | View/Open |
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