Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/118318
Title: Engineered muscle tissues for disease modeling and drug screening applications
Author: Mohammandi, M. H.
Obregón, Raquel
Ahadian, S.
Ramón-Azcón, Javier
Radisic, M.
Keywords: Músculs
Fisiologia experimental
Muscles
Experimental physiology
Issue Date: 1-Nov-2017
Publisher: Bentham Science Publishers
Abstract: Animal models have been the main resources for drug discovery and prediction of drugs’ pharmacokinetic responses in the body. However, noticeable drawbacks associated with animal models include high cost, low reproducibility, low physiological similarity to humans, and ethical problems. Engineered tissue models have recently emerged as an alternative or substitute for animal models in drug discovery and testing and disease modeling. In this review, we focus on skeletal muscle and cardiac muscle tissues by first describing their characterization and physiology. Major fabrication technologies (i.e., electrospinning, bioprinting, dielectrophoresis, textile technology, and microfluidics) to make functional muscle tissues are then described. Finally, currently used muscle tissue models in drug screening are reviewed and discussed
Note: Versió postprint del document publicat a: http://dx.doi.org/10.2174/1381612823666170215115445
It is part of: Current Pharmaceutical Design, 2017, vol. 23, p. 2991-3004
URI: http://hdl.handle.net/2445/118318
DOI: http://dx.doi.org/10.2174/1381612823666170215115445
ISSN: 1381-6128
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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