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Title: AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
Author: Herms, Albert
Bosch, Marta (Bosch Rodríguez)
Reddy, Babu J. N.
Schieber, Nicole L.
Fajardo, Alba
Rupérez, Celia
Fernández-Vidal, Andrea
Rentero Alfonso, Carles
Tebar Ramon, Francesc
Enrich Bastús, Carles
Parton, Robert G.
Gross, Steven P.
Pol i Sorolla, Albert
Keywords: Metabolisme dels lípids
Transport biològic
Lipid metabolism
Biological transport
Issue Date: 27-May-2015
Publisher: Nature Publishing Group
Abstract: Lipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of metabolic energy. While known to move bidirectionally along microtubules (MTs), the role of LD motion and whether it facilitates interaction with other organelles are unclear. Here we show that during nutrient starvation, LDs and mitochondria relocate on detyrosinated MT from the cell centre to adopt a dispersed distribution. In the cell periphery, LD-mitochondria interactions increase and LDs efficiently supply FAs for mitochondrial beta-oxidation. This cellular adaptation requires the activation of the energy sensor AMPK, which in response to starvation simultaneously increases LD motion, reorganizes the network of detyrosinated MTs and activates mitochondria. In conclusion, we describe the existence of a specialized cellular network connecting the cellular energetic status and MT dynamics to coordinate the functioning of LDs and mitochondria during nutrient scarcity.
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It is part of: Nature Communications, 2015, vol. 6, p. 7176
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ISSN: 2041-1723
Appears in Collections:Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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