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http://hdl.handle.net/2445/118640
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DC Field | Value | Language |
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dc.contributor.author | Cedó Giné, Lídia | - |
dc.contributor.author | García León, Annabel | - |
dc.contributor.author | Baila Rueda, Lucía | - |
dc.contributor.author | Santos, David | - |
dc.contributor.author | Grijalva, Victor | - |
dc.contributor.author | Martínez Cignoni, Melanie Raquel | - |
dc.contributor.author | Carbó, José M. | - |
dc.contributor.author | Metso, Jari | - |
dc.contributor.author | López Vilaró, Laura | - |
dc.contributor.author | Zorzano Olarte, Antonio | - |
dc.contributor.author | Valledor Fernández, Annabel | - |
dc.contributor.author | Cenarro, Ana | - |
dc.contributor.author | Jauhiainen, Matti | - |
dc.contributor.author | Lerma, Enrique | - |
dc.contributor.author | Fogelman, Alan M. | - |
dc.contributor.author | Reddy, Srinivasa T. | - |
dc.contributor.author | Escolà Gil, Joan Carles | - |
dc.contributor.author | Blanco-Vaca, Francisco | - |
dc.date.accessioned | 2017-12-12T15:10:33Z | - |
dc.date.available | 2017-12-12T15:10:33Z | - |
dc.date.issued | 2016-11-03 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/118640 | - |
dc.description.abstract | Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human apoA-I overexpression and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited breast cancer. Expression of human apoA-I in the mice did not affect tumour onset and growth in PyMT transgenic mice, despite an increase in the HDLc level. In contrast, D-4F treatment significantly increased tumour latency and inhibited the development of tumours. The effects of D-4F on tumour development were independent of 27-hydroxycholesterol. However, D-4F treatment reduced the plasma oxidized low-density lipoprotein (oxLDL) levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MCF-7 cells. In conclusion, our study shows that D-4F, but not apoA-I-containing HDL, hinders tumour growth in mice with inherited breast cancer in association with a higher protection against LDL oxidative modification | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/srep36387 | - |
dc.relation.ispartof | Scientific Reports, 2016, vol. 6, p. 36387 | - |
dc.relation.uri | https://doi.org/10.1038/srep36387 | - |
dc.rights | cc-by (c) Cedó et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Hiperlipoproteïnes | - |
dc.subject.classification | Ratolins transgènics | - |
dc.subject.classification | Pèptids | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | High density lipoproteins | - |
dc.subject.other | Transgenic mice | - |
dc.subject.other | Peptides | - |
dc.title | ApoA-I Mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 665488 | - |
dc.date.updated | 2017-12-12T15:10:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27808249 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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665488.pdf | 885.34 kB | Adobe PDF | View/Open |
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