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Title: GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma
Author: Moreno Monasterio, Marta
Pedrosa, Leire
Paré Brunet, Laia
Pineda, Estela
Bejarano, Leire
Martínez Soler, Fina
Balasubramaniyan, Veerakumar
Ezhilarasan, Ravesanker
Kallarackal, Naveen
Kim, Sung-Hak
Wang, Jia
Audia, Alessandra
Conroy, Siobhan
Marín Aguilera, Mercedes
Ribalta Farrés, Teresa María
Pujol Farré, Teresa
Herreros, Antoni
Tortosa i Moreno, Avelina
Mira, Helena
Alonso, Marta M.
Gómez-Manzano, Candelaria
Graus Ribas, Francesc
Sulman, Erik P.
Piao, Xianhua
Nakano, Ichiro
Prat Aparicio, Aleix
Bhat, Krishna P.
Iglesia, Núria de la
Keywords: Glioma
Issue Date: 21-Nov-2017
Publisher: Elsevier
Abstract: A mesenchymal transition occurs both during the natural evolution of glioblastoma (GBM) and in response to therapy. Here, we report that the adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits GBM mesenchymal differentiation and radioresistance. GPR56 is enriched in proneural and classical GBMs and is lost during their transition toward a mesenchymal subtype. GPR56 loss of function promotes mesenchymal differentiation and radioresistance of glioma initiating cells both in vitro and in vivo. Accordingly, a low GPR56-associated signature is prognostic of a poor outcome in GBM patients even within non-G-CIMP GBMs. Mechanistically, we reveal GPR56 as an inhibitor of the nuclear factor kappa B (NF-κB) signaling pathway, thereby providing the rationale by which this receptor prevents mesenchymal differentiation and radioresistance. A pan-cancer analysis suggests that GPR56 might be an inhibitor of the mesenchymal transition across multiple tumor types beyond GBM.
Note: Reproducció del document publicat a:
It is part of: Cell Reports, 2017, vol. 21, num. 8, p. 2183-2197
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ISSN: 2211-1247
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Infermeria Fonamental i Medicoquirúrgica)
Articles publicats en revistes (Medicina)

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