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http://hdl.handle.net/2445/119009
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DC Field | Value | Language |
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dc.contributor.author | Koepfli, Cristian | - |
dc.contributor.author | Ome-Kaius, Maria | - |
dc.contributor.author | Jally, Shadrach | - |
dc.contributor.author | Malau, Elisheba | - |
dc.contributor.author | Maripal, Samuel | - |
dc.contributor.author | Ginny, Jason | - |
dc.contributor.author | Timinao, Lincoln | - |
dc.contributor.author | Kattenberg, Johanna Helena | - |
dc.contributor.author | Obadia, Thomas | - |
dc.contributor.author | White, Michael T. | - |
dc.contributor.author | Rarau, Patricia | - |
dc.contributor.author | Senn, Nicolas | - |
dc.contributor.author | Barry, Alyssa E. | - |
dc.contributor.author | Kazura, James W. | - |
dc.contributor.author | Mueller, Ivo | - |
dc.contributor.author | Robinson, Leanne J. | - |
dc.date.accessioned | 2018-01-12T14:20:37Z | - |
dc.date.available | 2018-01-12T14:20:37Z | - |
dc.date.issued | 2017-09-19 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | http://hdl.handle.net/2445/119009 | - |
dc.description.abstract | Background: The scale-up of effective malaria control in the last decade has resulted in a substantial decline in the incidence of clinical malaria in many countries. The effects on the proportions of asymptomatic and submicroscopic infections, and on transmission potential are yet poorly understood. Methods: In Papua New Guinea, vector control has been intensified since 2008, and improved diagnosis and treatment introduced in 2012. Cross-sectional surveys were conducted in Madang Province in 2006 (n=1280), 2010 (n=2117) and 2014 (n=2516). Infections were quantified by highly sensitive qPCR and gametocytes by RT-qPCR. Results: P. falciparum prevalence by qPCR decreased from 42% in 2006 to 9% in 2014. P. vivax prevalence decreased from 42% in 2006 to 13% in 2010, but then increased to 20% in 2014. Parasite densities decreased 5-fold from 2006 to 2010; 72% of P. falciparum and 87% of P. vivax infections were submicroscopic in 2014. Gametocyte density and positivity correlated closely with parasitemia, and population gametocyte prevalence decreased 3-fold for P. falciparum and 29% for P. vivax from 2010 to 2014. Conclusions: Sustained control has resulted in reduced transmission potential but an increasing proportion of gametocyte carriers are asymptomatic and submicroscopic and represent a challenge to malaria control. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1093/infdis/jix507 | - |
dc.relation.ispartof | The Journal of Infectious Diseases, 2017, vol. 216, num. 11, p. 1434–1443 | - |
dc.relation.uri | http://dx.doi.org/10.1093/infdis/jix507 | - |
dc.rights | cc by-nc-nd (c) Koepfli et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Malària | - |
dc.subject.classification | Papua Nova Guinea | - |
dc.subject.other | Malaria | - |
dc.subject.other | Papua New Guinea | - |
dc.title | Sustained malaria control over an eight-year period in Papua New Guinea: the challenge of low-density asymptomatic infections | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2017-11-01T19:00:05Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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jix507.pdf | 661.9 kB | Adobe PDF | View/Open |
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